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The use of Bacillus anthracis as a bioterrorist agent, in 2001, resulted in the death of 5 individuals. The pathogenicity of anthrax is due to the proteolytic effects of one of its components: the enzyme lethal factor (LF). LF's substrate is located within the cytosol of cells and its cleavage results in a silencing of the interleukin-6 (IL-6) cytokine signaling pathway. The entry of LF into the cytosol...
Whooping cough has globally resurfaced due to the suboptimal quality of the traditional vaccines, cyclic variations in its pattern and discovery of new strains of the causative agent, Bordetella pertussis. Our studies provide a proof of principle for the development of a novel, solid state vaccine to counter the disease by successfully immobilizing pertussis toxin (PT), which is 200 times larger than...
H5N1 has been identified as the most pathogenic strain of avian flu, and therefore has been the most studied in prospective vaccine strategies. The grim reality of material and personnel shortage during a pandemic renders all of the currently proposed technologies inadequate for rapid mass vaccination. The long term goal of this project is to develop a transdermal patch containing a nanoencapsulated...
Bacillus anthracis, the bacterium which causes anthrax, has been a source of major concern since the deadly series of contaminated postal letters back in 2001. The three main proteins secreted by the bacterium are protective antigen (PA), lethal factor (LF), and edema factor (EF), and are the cause of its virulent effect. With the impeding threat of bioterrorist attacks, studies have been undertaken...
The outermost layer of skin represents an effective, but fragile barrier to the hostile microbial world. Transdermal, and transcutaneous delivery have been constrained by the well accepted paradigm of size limitation for skin penetration. This study utilized the electrospinning method to create nanofiber membranes of horseraddish peroxidase (HRP) and polyvinylpyrrolidone (PVP). The coating was deposited...
Global resurgence of whooping cough, a highly contagious disease caused by the fastidious gram negative coccobacillus, Bordetella pertussis, has raised questions of the current preventative and treatment technologies. A novel non-invasive vaccine has been developed by immobilization of Pertussis Toxin (PT) in electrospun polymer (Polyvinylpyrrolidone, PVP) nanofibers. In vitro experiments were utilized...
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