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Pittsburgh compound B Positron Emission Tomography (PiB PET) imaging is a new technique to detect amyloid-beta (Aβ). Aβ is a pathological bio-data which appears distinctly in most neuro-degeneration diseases, such as Alzheimer's disease (AD). Although PiB PET imaging is relative mature, the accurate diagnosis of AD based on PiB PET images still remains a challenge for radiologists. To solve above...
Blood vessel extraction from retinal fundus images is an important task in developing the computer-aided diagnostic system for ophthalmologists. In this paper we have presented an algorithm for extraction of blood vessels of retinal fundus images and comparison of different moment invariants used for the extraction of features for the vessel pixels. The algorithm uses neural networks for distinguishing...
With the rapid maturity of internet and web technology over the last decades, the number of Indonesian online news articles is growing rapidly on the web at a pace we never experienced before. In this paper, we introduce a combination of rule-based and machine learning approach to find the sentences that have tropical disease information in them, such as the incidence date and the number of casualty,...
The diagnosis of the arythema disease is a real difficulty in dermatology. It causes redness induced in the lower level of the skin by hyperemia of the capillaries. It can harm several skin damages, inflammations. In this paper, we have put our efforts to design a diagnostic approach based on Support Vector Machine (SVM) with linear kernel by classifying the erythemato-squamous disease. SVM being...
This paper presents an efficient Parkinson disease diagnosis system using Least Squares Twin Support Vector Machine (LSTSVM) and Particle Swarm Optimization (PSO). LSTSVM is a promising binary classifier and has shown better generalization ability and faster computational speed. PSO is used for feature selection and parameter optimization. Parkinson disease dataset is taken from UCI repository. The...
In biomedical area, information is mainly in natural language text format. Such information is stored in huge repositories. It is not easy to access required information from this large amount of data. Also the classification systems developed for general text is not applicable for biomedical data. The biomedical researchers need fast and accurate information accessing tools for extracting useful...
Indirect immunofluorescence imaging is employed as a standard method to detect antinuclear antibodies in HEp-2 cells which is important for diagnosing autoimmune diseases and other important pathological conditions involving the immune system. HEp-2 cells are generally categorised into six groups: homogeneous, fine speckled, coarse speckled, nucleolar, cytoplasmic, and centromere cells, which give...
Jamu is made from natural materials such as roots, leaves, timber and fruits. Jamu has many variations of formula. The composition of Jamu formula is usually based on empirical data or personal experiences. Thus, the classification for the efficacy of Jamu based on its compositions of plants still remains an interesting task. The purpose of this research is to develop a classification system for Jamu...
Feature selection is a vital process in classification of medical datasets. This paper addresses feature selection in Radial Basis Function (RBF) kernel space for the classification of multiclass dermatology dataset using neural network and data mining classifiers. It has three stages in determining relevant and irrelevant features for the classification task. In stage I, the features of dermatology...
This article introduces a computer-aided diagnosis system of the heart valve disease using binary particle swarm optimization and support vector machine, in conjunction with K-nearest neighbor and with leave-one-out cross-validation. The system was applied in a representative heart dataset of 198 heart sound signals, which come both from healthy medical cases and from cases suffering from the four...
Support vector machine is a widely used tool in the field of image processing and pattern recognition. The parameters selection plays a significant role in support vector machine(SVM). This paper proposed an improved parameter optimization method based on traditional PSO optimizing algorithm by changing the fitness function in the traditional process. And this method has achieved better results which...
Alzheimer's disease (AD) is one major cause of dementia. Previous studies have indicated that the use of features derived from Positron Emission Tomography (PET) scans lead to more accurate and earlier diagnosis of AD, compared to the traditional approach used for determining dementia ratings, which uses a combination of clinical assessments such as memory tests. In this study, we compare Naïve Bayes...
This paper shows a machine learning approach based on Principal Component Analysis (PCA) and Support Vector Machine (SVM) to compare the diagnostic accuracy on very early Alzheimer's Disease (AD) patients with 18F FDG and Pittsburg Compound B (PiB) PET imaging. The Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset is used for testing, making use of the longitudinal character. Mild Cognitive...
With the rapid development of high-throughput genotyping technologies, more and more attentions are paid to the disease association study identifying DNA variations that are highly associated with a specific disease. One main challenge for this study is to find the optimal subsets of Single Nucleotide Polymorphisms (SNPs) which are most tightly associated with diseases. Feature selection has become...
The MMPs and ADAMs are cell surface proteases which belong to metalloprotease family. They play an important role in skin aging, skin disorders, anticancer therapy and other physiological disorders. Thus there arises the need to understand the relationships among various parameters of these proteins for prediction of their classes, structures and functionality. The computational approaches for prediction...
Electrocardiographic T wave peak-to-end interval (TpTe) is one parameter of T wave morphology, which contains indicators for hypoglycaemia. This paper shows the corrected TpTe (TpTec) interval as one of the inputs contributing to detect hypoglycaemia. Support vector machine (SVM) and fuzzy support vector machine (FSVM) utilizing radial basis function (RBF) are used as the classification methods in...
Artificial intelligence techniques have been extensively used for the identification of several disorders related with the voice signal analysis, such as Parkinson's disease (PD). However, some of these techniques flaw by assuming some separability in the original feature space or even so in the one induced by a kernel mapping. In this paper we propose the PD automatic recognition by means of Optimum-Path...
This paper presents a computer-aided diagnosis technique for improving the accuracy of the early diagnosis of the Alzheimer type dementia. The proposed methodology is based on the calculation of the skewness to each m-by-m sliding block of the transaxial slices of the SPECT brain images. We replace the center pixel in the m-by-m block by the skewness value and build a new 3-D brain image which will...
Syndrome is a unique TCM concept, which is an abstractive collection of symptoms and signs. Several modern algorithms have been applied to classify syndromes, but no satisfied results have been obtained because of the complexity of diagnosis procedure. Support vector machine (SVM) has been found to be very efficient to solve the classification problems, especially for binary classification with good...
This paper shows a new computer aided diagnosis (CAD) technique for the early Alzheimer's disease (AD) based on single photon emission computed tomography (SPECT) image feature selection and a statistical learning theory (SLT) classifier. Conventional evaluation of SPECT is time consuming, subjective and prone to error because images often rely on manual reorientation, visual reading of tomographic...
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