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RNA-seq has the potential to discover genes created by complex chromosomal rearrangements. 'Fusion' genes formed by the breakage and re-joining of two different chromosomes have repeatedly been implicated in the development of cancer. However, although RNA-seq can detect these fusion events, normal cells are also characterized by read-through fusions across adjacent genes in the genome, or by transcription-induced...
Five lactobacillus strains which were obtained from traditional fermented foods in western China, were examined for use as probiotics and for anticancer biological products. The cell walls and cytoplasm extracts from lactobacillus strains were tested for anti-proliferative activity and induction of apoptosis. The results showed the cell walls showed significant direct anticancer activity. 16S rRNA...
The expression of TNF super family member often undergoes post-translation modifying, including internalization and shedding by specific enzymes. Matrix metalloproteases (MMPs) and proteases containing a disintegrin and a metalloprotease domain (ADAMs) are often responsible for the shedding of these members. But the proteases shedding TNF-related apoptosis inducing ligand (TRAIL, a newly described...
To examine the expression status of TSP50 in different types of human tumors. we tested the expression of TSP50 in Lung cancer, stomach cancer, liver cancer, colon cancer and prostate cancer by performing IHC assays technique. the expression of TSP50 in Lung cancer indicated that the positive rate was about 89%; the expression of TSP50 in stomach cancer the positive rate was about 88%; the expression...
To investigate the role of the angiopoietin-2 (Ang-2) signal transduction pathway in colon cancer, colon cancer cells (SW1116) were divided into four groups, control group, serum-free group, Ang-2 group (treated with 1.2 mg/L Ang-2) and PI3K/Akt inhibitor group (treated with LY294002 and Ang-2). Then Tie-2, PI3K and Akt were detected via Western blotting after 24 h. Compared to the serum-free group,...
In order to establish a novel technique of separation and analysis of EGCG from tea polyphenols using high-speed countercurrent chromatography (HSCCC), a set of HSCCC apparatus was applied to isolate and purify EGCG from tea polyphenols using two-phase solvent system composed of n-hexane-ethyl acetate-ethnol-water-acetic acid (1:5:1:5:0.25, v:v) in tail to head elution model, which the upper phase...
A novel methodology to identify L1 Ta-1 insertion events in human patient tissue samples using high-throughput pyrosequencing was developed. Using this method, many new L1 Ta-1 insertions were identified. One novel L1 Ta-1 insertion was identified in a tumor tissue DNA, but was absent in the adjacent normal tissue DNA. These results suggest that L1 Ta-1 insertions can occur during colon cancer development,...
In this paper we present a global analysis of colon rectal cancer genes and their associated miRNAs. Significant genes in colon cancer were obtained by mining the literature and cancer related miRNAs were obtained from miRbase. Five different features were used to analyze to obtain a global gene-miRNA profile. By combining the topological features along with miRNA-gene associations and gene propensity...
This research visualizes the spatial patterns of diagnosed colon and lung cancer mortalities across the New York State. Kernel density analysis was applied to visualize the spatial patterns of old industrial sites across the state. Geographically Weighted Regression (GWR) was applied to model the possible pollution impact of old industrial sites on colon and lung cancer incidents. GWR is a local spatial...
The identification of disease microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. However, one major issue in microRNA studies is the lack of bioinformatics methods to accurately predict disease-related microRNAs. Herein, we proposed an approach for prioritizing disease-related...
Objective: To study the effect of hesperidin extracted from the peel of Gannan kumquat on cell proliferation and apoptosis of human poorly diferentiated nasopharyongeal carcinoma epithelial cell (CNE-2Z). Methods: Effect of hesperidin on proliferation of CNE-2Z cells was detected by the MTT method. Effect of hesperidin on apoptosis of CNE-2Z cells was utilized by the acridine orange / ethidium bromide...
The aim of this paper is to introduce a variational image segmentation method for assessing the aberrant crypt foci (ACF) in the human colon captured in vivo by endoscopy. ACF are thought to be precursors for colorectal cancer, and therefore their early detection may play an important clinical role. We enhance the active contours without edges model of Chan and Vese to account for the ACF's particular...
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