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The aim of this study was to investigate the risk of proarrhythmia by dofetilide in gender and age based differences using action potential duration and triangulation of action potential. Left ventricular epicardial, midmyocardial and endocardial action potentials were simulated using a modified Luo Rudy model. Sex, age and regional differences in current densities and voltage dependent parameters...
In this work we present a new electromechanical cardiac myocyte model tailored to reproduce the electrical and force generating activities of human ventricular myocytes. The model was created by coupling two existing models: the ten Tusscher electrophysiology model and the Rice myofilament mechanics model. The parameters of the new model were adjusted in order to replicate the available experimental...
Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter set. This parameter set can contain some elements that are fitted to experimental data independently of any other element, some elements that are derived concurrently with other elements to match experimental data, and some elements that are derived purely from phenomenological fitting to produce the...
Cardiac arrhythmias are mainly due to failure in the coordination among contraction of cardiac muscle. Among several types of arrhythmias, we focused on ventricular reentrant arrhythmia because it is more dangerous arrhythmia. With the help of detailed biophysical model of human ventricular cell, the role of sodium ion concentration and calcium currents on single and one-dimensional array of cells...
Results from recent experiments undertaken on tissue from the gastrointestinal (GI) tract suggests that the interstitial cells of cajal (ICC) are the pacemaker cells responsible for slow wave propagation. The pace-making mechanism of ICC networks is strongly dependant on intracellular spatial dynamics of Ca/sup 2+/. A modeling framework has being developed to test the hypothesis of voltage-dependant...
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