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The aim of this study was to investigate the risk of proarrhythmia by dofetilide in gender and age based differences using action potential duration and triangulation of action potential. Left ventricular epicardial, midmyocardial and endocardial action potentials were simulated using a modified Luo Rudy model. Sex, age and regional differences in current densities and voltage dependent parameters...
The aim of this study was to investigate interactions between acquired long QT syndrome by dofetilide and reduced repolarization reserve in simulated human ventricular cells using prolongation of APD and triangulation of action potential. A Markovian model of hERG capable of reproducing a wild type as well an acquired long QT syndrome by dofetilide was developed and was included into a ventricular...
The main goal of this work was to design, develop and test a new system for Integral community cardiac rehabilitation phase III (CR-III) based on technological platforms for the LCSS's (Lifestyle Change Supporting System). The system has the following characteristics: personalized cardiac rehabilitation program, automatic support in establishing and modifying care program, risk factor ,monitoring...
It is well known that short-long (S-L) sequences frequently precede the onset of malignant ventricular arrhythmias. Experimental studies have shown that a single long coupled extra-beat (L) after a previous basic cycle length resulted in a critical increase of the dispersion of repolarization pattern that promoted reentrant excitation. However, in normal intact heart little differences in repolarization...
A computer model has been developed in which reflection was observed. Reflection is a type of reentry in a one-dimensional structure of cardiac cells. The model consists of two segments of ventricular tissue partially coupled by a coupling resistance (R) and it was used to study conditions that provoke the development of EADs, and the generation of reflection and ectopic activity. In the present study,...
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