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Objective: To investigate the effect of Turmeric extract on rats acute myocardial ischemia model. Method: rats acute myocardial ischemia model, detect the SOD of blood plasma red blood cell and the content of SOD in tissue with SOD kit to reflect the level of SOD in tissue cells, to understand the produce rate of oxygen free radical in vivo and the degree of peroxidation action in lipid. Conclusion:...
In guideline E14, the American Food and Drug Administration (FDA) requests for clinical studies to investigate the prolongation of the heart rate corrected QT-interval (QTc) of the ECG. As drug induced QT-prolongation can be caused by changes in the repolarisation of the ventricles, it is so far a thorough ECG biomarker of risk for ventricular tachyarrhyth-mias and Torsade de Pointes (TdP). Ventricular...
How to screen active components of herbal drugs is still a hot topic of pharmacologists and pharmaceutical chemists. The main aim of the study was to establish a strategy to tract the active components in early stage based on the fact, that a compound (component) can not take systematic effect without binding to a biomolecule of organism. Affinity constants (KD or KD) and relative affinity indexes...
Abstract-The effect of indigestible dextrin on blood glucose and blood lipids in diabetic mice was investigated in this study. Methods Diabetic mouse model was established by intraperitioneal injection of alloxan. Low, middle and high doses of indigestible dextrin with the concentration of 10%,25% and 50% aqueous solutions were given respectively to diabetic mice following lavage. The fasting blood...
This study proposed a Polydimethylsilcoxane (PDMS) concentration gradient microfluidic chip fabricated using MEMS, casting molding, and microimprinting technology. The chip is used to research on optimizing concentration of endothelial cells on glucose concentration gradient is extracted using this chip. In the experiment a concentration gradient in solution was generated by a microfluidic network,...
Pyridostigmine is a reversible inhibitor of acetylcholinesterase (AChE). The objective of the present analysis was to characterise the population pharmacokinetics / pharmacodynamics (PK/PD) of pyridostigmine given as pyridostigmine bromide. Fifty healthy Chinese males received 7 doses of 30 mg of pyridostigmine bromide each every 8 hours orally. Plasma concentrations of pyridostigmine and red blood...
To investigate the pharmacokinetics of loganin in rat plasma which is administered total glycoside (TG) of Jinkuishenqi pill with three different doses and the influence of verapamil. The three different doses (2.95 4.43 5.90 gmiddotkg-1)of TG alone or TG(5.90 gmiddotkg-1) in combination with verapamil (10 mgmiddotkg-1) was administered to Wistar rats. Serial blood samples of loganin were measured...
This paper presents the first microneedle-based transdermal patch with integrated active dispensing functionality. The electrically controlled system consists of a low-cost dosing and actuation unit capable of controlled release of liquid in the microliter range at low flow-rates and minimally invasive, side-opened, microneedles. The system was successfully tested in vivo by insulin administration...
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