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We report a resonant frequency-domain terahertz (THz) near-field probe setup and its application in imaging a slice of a mouse brain slice and the leaf of a dwarf umbrella tree. In our probe setup, we coupled the waveguide output of a terahertz Vector Network Analyzer (VNA) system to feed a horn antenna and then used the horn antenna to excite a sharp iron or Teflon tip. The tip transforms and concentrates...
3D needle-type glass waveguide arrays were developed as potentially compact neural interfaces for light delivery in deep-tissue. As much as 90% of input light is transmitted via a single optrode to depths >1mm in tissue. Light emission profiles from the optrode tips into tissue can exhibit beam widths of 70–150 μm and full-angle divergence ranging from 13–40°. These beam characteristics may be...
The subgranular zone of the dentate gyrus of sexually mature mice contains a highly variable number of pluripotent stem cells that produce a stream of intermediate progenitors which give rise to neurons and glial cells. Genetic factors, age, and the environment control variation in the fate and rate of neurogenesis. Discovery of stem cells in the adult CNS has catalyzed wide-ranging research into...
Substantial advancement in the understanding of the neuronal basis of behavior and the treatment of neurological disorders has been achieved via the implantation of various devices into the brain. To design and optimize the next generation of neuronal implants while striving to minimize tissue damage, it is necessary to understand the mechanics of probe insertion at relevant length scales. Unfortunately,...
The current generation of stereotaxic neurosurgery systems uses CT or MRI images and a small laptop computer system to determine the coordinates of the target and burr hole entry points. The detail provided by the anatomical atlas is lost. A system is described whereby neuroanatomic atlases mapped onto CT or MRI images provide the neurosurgeon with both the detail of the atlas and the patient-specific...
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