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To evaluate the influence of methylenetetrahydrofolate reductase (MTHFR) 1298 A→Cpolymorphisms on response to transarterial chemoembolization (TACE) treatment for primary hepatocellular carcinoma (HCC). 125 patients with HCC were treated with TACE alone. Of them, 63 patients underwent TACE using lipiodol mixed with cisplatin(DDP), Pirarubicin(THP) and mitomycin(MMC), and 62 patients underwent TACE...
Goat pox is contagious viral diseases of small ruminants and are caused by goat pox virus that belong to genus Capripoxvirus of Poxviridae family. The disease epidemics cause significant economic losses for sheepindustry. This communication highlights clinico-epidemiological observations from the four goat pox outbreaks in Xinjiang China in 2010. In clinical signs, fever, multisystemic nodular lesions,...
Ultrasound mediated delivery (USMD) in the presence of microbubbles is a potentially safe and effective method for gene therapy, offering many desired characteristics such as low toxicity, potential for repeated treatment, as well as organ specificity. In this study we tested the capability of USMD to improve gene transfection to mice livers for treating a rare genetic disorder, Glycogen Storage Disease...
Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model consisting of two differential equation systems that enable us to describe and understand the dynamics of host cells, virus and the immune system. Our model provide a possible interpretation for the effect of combination...
Based on the clinical data of acute hepatitis B patients and the HBV infection dynamic model proposed by Nowak et al., we construct a mathematical model to describe and understand the dynamics of host cells, virus and the immune system during the acute stages of the infection. Our model provide a possible interpretation for the phenomenon of acute hepatitis and acute-turn-chronic hepatitis. Based...
Based on a patient's anti-hepatitis B virus (HBV) infection therapy clinical data of a new type of Chinese herbs (NTCH, consisting of 13 ingredients) plus adefovir dipivoxil, and our previous modified basic virus infection model [1], a new differential equation model with an immune variable is set up, and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well...
In molecular biology, Gene Ontology (GO) has often been used for annotation and as a data mining dimension. A frequently performed step in microarray analytics is the clustering of co-expressed genes by their GO bioprocesses. Biological deductions are then made from the visual representation of the cluster pattern. Thus far, the question of how different representations of GO-annotated clusters affect...
IgE plays essential roles in the pathogenesis of many allergic disorders including bronchial asthma, allergic rhinitis, atopic dermatitis, and anaphylaxis. If IgE production can be effectively and safely controlled in patients, such procedures may alleviate allergic symptoms, leading to novel therapeutic and prophylactic interventions of allergic diseases. Interleukin-21 (IL-21) is a cytokine produced...
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