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Worldwide, cancers are the leading causes of human mortality. To successfully treat advanced-stage cancers, it is important to increase cytotoxicity of targeted tumor cells while reducing side effects on normal cells during radiotherapy. Nanotechnology provides a promising solution to achieve this targeted treatment[1-3]. An ideal strategy is to develop effective nanoscale radio-sensitizers targeting...
Nanofluidic structures, such as nanochannels have been successfully used to confine and stretch DNA molecules, offering the opportunity of investigating on their conformational changes. Moreover, the integration of these confinement systems on lab-on-chips has shown a great potential for applications such as biomolecule sieving or single molecule manipulation. Arrays of nanochannels are fabricated...
The development of high-sensitivity and specificity probes that lack the intrinsic limitation of organic fluorescent dyes and sensitizers is of considerable interest in many areas of research, from cellular biology to molecular imaging and diagnostics. Quantum dots (QDs) are stable, bright fluorophores that can give high quantum yields, narrow emission bands, intense absorbance, very large Stokes...
This paper describes the synthesis of Fe3O4/Poly[3-(trimethylamlno)ethyl methacrylate iodine] (PTMAI) /CdTe bifunctional nano gene vector for targeting DNA delivery. In this approach, Poly[2-(dimethylamlno)ethyl methacrylate] (PDMA) was grafted on the Fe3O4 nanoparticles by surface-initiated transfer radical polymerization (ATRP). The ternary amine groups of PDMA can be alkylated by the iodomethane...
Boron nitride nanotubes are structural analogues of carbon nanotubes with alternating B and N atoms, which entirely substitute for C atoms in a graphitic like sheet. In this study, we investigated the interactions of boron nitride nanotubes with C2C12 cells as model of muscle cells. We demonstrated that they do not affect viability of these cells neither interfere with their differentiation, making...
Nanoparticles (NPs) with carbohydrates as functional ligands are called glyconanoparticles, which has a multifunctional role in biomedical nanotechnology. The development of new class of functionalized nanoparticles with biologically relevant applications is of high potential in the field of nanotechnology. To this regard pharmacologically active naturally occurring amino sugar, glucosamine (GlcN)...
The use of carbon nanotubes (CNTs) as vectors for targeted drug delivery was recently considered, thanks to their ability to permeate the cellular membrane which, instead, results highly refractory to transfer with other vectors (viral and not viral). Our project is devoted to define and characterize a CNTs based nanocompound for gene-moduling, with the final aim of complementing defective functions...
Hydrogen bonds have important role in bio-nanotechnology and have particularly significant meaning in the recognition bonding of double stranded DNA. Furthermore the bonds are used in a reading process by the artificial DNA sequence reader, and they determine characteristics of the currents through the header atom probes. As two principal factors in various interaction energies in the hydrogen bond,...
We report the description of a new low cost method to create a device based on a chemically modified nanopore created on a polymeric membrane. Using Soft-Lithography and Nanofabrication it can be possible to create a nanopore on a free standing polymeric membrane. After oligonucleotide functionalization of the lumen of the nanopore it is possible to detect specific sequences of DNA, thanks to the...
Desmosomes are cell-cell junctions that provide mechanical strength for cells and maintain integrity of tissues in animal skins and hearts. Disruption of the desmosome like in some autoimmune diseases will therefore change the mechanical property of the anchoring cells and causing blistering. In the paper, we used Atomic Force Microscopy (AFM) to visualize the keratinocytes intercellular structure...
Presented application is based on the use of carbon nanotubes for biomolecular analysis using electrochemiluminescence (ECL) detection technique ([1]-[9]). ECL is the generation of light by electron transfer between species electrochemically generated. ECL research has led to the successful ultrasensitive analysis of biomolecules in solution and commercialisation of several generations of ECL analyzers,...
The assembly of DNA nanostructures can allow for promising nanometer-sized machines. Synthetic DNA motifs are known to assemble into a wide range of nanoarchitectures by sequence programming. For the purpose of constructing strictly-controlled biological nanomachines, we design the self-assembly system consisting of DNA strands with the ability of producing a functional molecule. In this work we demonstrate...
Systemic chemotherapy is widely used for treatment of metastatic colorectal cancer (CRC). However, many CRC patients show poor response to chemotherapy and suffered from toxicities. Thus, prediction of chemotherapy response is very important in effective therapy. In the present study, we investigated whether chemotherapy response of CRC can be predicted by nano-assisted laser desorption/ionization...
In this article we have provided an overview of current approaches related to biomedical informatics (BMI), GRID, and genomic medicine, particularly in Europe. Research on areas such as ontologies, data mining, information retrieval, or semantic interoperability is redefining current informatics methodologies to support biomedical research. While traditional disciplines such as BI, MI, and neuroinformatics...
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