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Liposomes are nanoparticles consisting of phospholipid-bilayer membranes and aqueous compartments. They can effectively incorporate both hydrophobic and hydrophilic molecules, and therefore have been widely applied as a carrier for gene and drug delivery. Moreover, liposomes are considered as a novel vaccine delivery system, which encapsulate both Antigen (Ag) and immunomodulatory agents, facilitating...
In this report, we detailed the design and fabrication of a nitric oxide (NO) sensor for cell culture measurements. As an example, we considered NO sensor design for hypoxic cell culture applications (cells which can proliferate at less than 4% oxygen concentration). Primarily, a set of 2D, steady state, reaction coupled diffusion simulation is performed. The simulation results suggest the optimal...
In this paper, we introduce a method of functionally classifying lung cancer cells from normal cells by using Tetrakis Carboxy Phenyl Porphine (TCPP) and well-known computational intelligent techniques. Tetrakis Carboxy Phenyl Porphine (TCPP) is a porphyrin that is able to label cancer cells due to the increased numbers of low density lipoproteins coating the surface of cancer cells and the porous...
Study the role of Fas ligand (FasL) expression in carcinogenesis and progression of esophageal cancer and molecular mechanisms of relevant immune escape. FasL expression was studied in adjacent epithelial cells, cancer cells and lymphocytes of primary foci, and cancer cells of metastatic foci from 40 cases of esophageal cancer by immunohistochemistry. The relationship between FasL expression in cancer...
Saikosaponin D is a saponin extract derived from several species of Bupleurum (Umbelliferae), which is used for the treatment of various liver diseases in traditional Chinese medicine. In this study, we report that Saikosaponin D inhibits the cell growth of human lung cancer cell line A549 and provide a molecular understanding of this effect. The results showed that Saikosaponin D inhibited the proliferation...
The objective of this study is to investigate the relationship between caspase-3 expression and apoptosis in the gastric adenocarcinoma cell line SGC-7901 transfected with the adenovirus-mediated FasL gene. The human gastric adenocarcinoma cell line SGC-7901 was transfected with the adenovirus-mediated FasL gene. The expression of caspase-3 and apoptotic morphological changes were measured by flow...
Tumour invasion and metastatic dissemination depends on cell motility, a process that may be studied and quantitatively evaluated by analysing multidimensional digital images. Current methods allow to keep track of the paths followed by specific objects and perform statistical analysis on the recorded data. By adapting a set of tools, independently developed for studying cell movement, to work with...
To study the effect of Saponins of asparagus on HepG2 apoptosis, reactive oxygen species (ROS) and mitochondrial membrane potential (Deltapsim) levels. Saponins of asparagus with different concentration was treated with HepG2 at different time, MTT assay was used to detect inhibitory rate, fluorescence staining was used to observe apoptosis morphology, flow cytometry was used to detect apoptosis rate...
To observe the effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells, and to uncover the mechanism by which solanine induces apoptosis. HepG2 cells are double stained with TMRE and Fluo-3/AM, and both the change in membrane potential of mitochondria and that of [Ca2+]i in the cells are observed using LCSM. The results of double staining with TMRE and...
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