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Nowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to investigate the feasibility of a non-genetic approach to personalized therapy, via the point-of-care drug monitoring in biological fluids with electrochemical...
A critical issue in bioelectrochemical applications, that use electrodes modified by nanomaterials, like enzyme sensor modified by Single Wall Carbon Nanotubes (SWCNTs), is to ensure high activity of the active center of an immobilized enzyme protein. GOx as a classical enzyme with cofactor has been investigated by experimental and in silico simulation to discover and understand the molecular mechanism...
A mediatorless sensor device based on a glassy carbon electrode modified by a hyaluronic acid (HA) dispersed carbon nanotubes (CNTs) for detection of NADH in a flow injection mode was prepared with good operational stability.
This paper outlines the fabrication and characterization of an immunosensor based on electrochemical, biological, and nano-material techniques to achieve high sensitive detection of Escherichia coli (E.coli). The working electrode consists of E.coli antibody/antigen/horse-radish peroxidase (HRP) labeled antibody immobilized on plasma-functionalized multiwalled carbon nanotube (pf-MWCNT) film. Immunosensors...
Presented application is based on the use of carbon nanotubes for biomolecular analysis using electrochemiluminescence (ECL) detection technique ([1]-[9]). ECL is the generation of light by electron transfer between species electrochemically generated. ECL research has led to the successful ultrasensitive analysis of biomolecules in solution and commercialisation of several generations of ECL analyzers,...
Carbon nanotubes have a high electrochemically accessible area of porous tubes, good electronic conductance and strong mechanical property. These properties essentially suggest that CNTs are attractive materials for the construction of nanoscaled biosensors. Ligand frameworks such as the Schiff base containing salen ligand, that can be sterically and electronically modified with ease, are very attractive...
The carbon nanotube modified biosensors for respectively monitoring uric acid (UA) and total cholesterol in blood were studied. The transducers were based on two screen-printed carbon electrodes, a carbon working electrode and a reference electrode. For UA sensors, uricase was immobilized on the surface of electrodes together with potassium ferrocyanide as electron transfer mediator. For cholesterol...
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