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CD151 plays an important role in the regulation of cell migration, vascular morphogenesis, and cancer metastasis. Many of these processes are related to the strength of cell-matrix attachment. In this study, traction force microscopy (TFM) was used to determine whether knockdown of CD151 in endothelial cells would lead to a significant modification in cell-matrix adhesion. Human dermal microvascular...
The aim of this paper is to introduce effects well known to clinicians -but neglected to date- in the biomechanical modelling of breast malignant tumours. We develop a model of an isolated stellate breast tumour under mammographic compression forces. We study a range of reported mechanical properties, both linear elastic and hyperelastic. We also introduce different volumes of increased density/stiffness...
Background: Treatment of malignant tumors of the pelvis, especially in the periacetabular region continues to present one of the most challenging problems in oncological and orthopedic surgery. Even now, hindquarter amputation is still the only choice for some patients, but hindquarter amputation can cause much trouble in sitting, standing and in fitting the exoprosthesis of patients after amputation,...
One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic...
The effect of flow acceleration, rather than just the flow rate, on the response of an attached cancer cell is for the first time reported. Selective binding of prostate cancer cells to a surface functionalized with anti-N-cadherin antibodies utilizing a microfluidic system under flow conditions has been studied. Here, the behavior of a captured cell under a time-dependent flow field is investigated...
Blood loss is a concern in the liver resections. In line with the wide implementation of ablation process, bleeding during liver resections can be minimized. However, the division process has to be accurately monitored to provide efficient liver resection in terms of time and safety. The modeling of liver tissue and division tool interaction along with the deformation of the liver tissue is studied...
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