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The high affinity receptor for IgE (FcɛRI) is constitutivelly expressed on the surface of mast cells and basophils as a multimeric complex. Upon antigen ligation to FcɛRI-bound IgE molecules, the receptor complex transduces intracellular signals leading to the release of preformed and newly synthesised pro-inflammatory mediators.FcɛRI engagement also generates negative intracellular signals involving...
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