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Voltage-gated ion channel is the molecular target for a broad range of toxins. Voltage-gated ion channel toxins are excellent pharmacological tools in toxicology and neuroscience. They have been used as molecular scaffolding agents, drugs, and insecticides. In this study, voltage-gated calcium, potassium and sodium channel toxins are predicted by the increment of diversity (ID) algorithm. Each protein...
Chloroplasts are organelles in most green plant and some algal cells. Identifying protein subchloroplast localization in chloroplast organelle is very helpful for understanding the function of chloroplast proteins. There have existed a few computational prediction methods for protein subchloroplast localization. However, these existing works have ignored proteins with multiple subchloroplast locations...
G-Protein-Coupled Receptor (GPCRs) play a key role in cellular signaling networks that regulate various physiological processes. The functions of many of GPCRs are unknown, because they are difficult to crystallize and most of them will not dissolve in normal solvents. This difficulty has motivated and challenged the development of a computational method which can predict the classification of the...
Neurotoxins can be divided into presynaptic neurotoxins and postsynaptic neurotoxins based on their mechanism of action. The two neurotoxins have important application in basic research and drug design. Presynaptic neurotoxins have been used for treatment of migraine headache and cerebral palsy. Therefore, the successful prediction of these two neurotoxins is becoming very important in recent years...
In the protein universe, many proteins are composed of two or more polypeptide chains, generally referred to as subunits, which associate through noncovalent interactions and, occasionally, disulfide bonds. With the number of protein sequences entering into data banks rapidly increasing, we are confronted with a challenge: how to develop an automated method to identify the quaternary attribute for...
Identifying the function of proteins is one of the major goals in cell biology and proteomics. Protein subcellular localization is a key functional characteristic of proteins and correct prediction of protein subcellular localization will greatly help in understanding its functions. Based on the concept of the pseudo amino acid composition (PseAA) by which a considerable amount of sequence-order effects...
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