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Chemical characterization of illicit drugs, like cocaine, is important to provide chemical and physical information to assist police agencies to understand drug trafficking and identify drug origin. In this context, the present work shows the use of an electrochemical sensor containing two working electrodes (pt and GC) to extract voltammetric information about cutting agents added to cocaine (procaine,...
The viability of cells cultured in systems for drug screening purposes is usually tested with a variety of colorimetric/fluorescent methods. In this work, we propose an alternative way of assessing cell viability — SIA (sequential injection analysis) electronic tongue (hybrid type, with potentiometry, amperometry and spectrophotometry techniques applied). It is shown, that the presented device is...
Novel drug delivery systems, which facilitate swallowing and improve patient adherence due to bitter taste masking of Active Pharmaceutical Ingredient (API), gain an increasing interest in recent years. Usually, studies on the taste of pharmaceutical products are conducted by human taste panel, but it concerns ethical doubts. Electronic tongue is one of the candidate tools allowing for fast, repeatable,...
Anti-psychotic drugs and its effects on various neurotransmitters have been studied tremendously in the past few years. Here, we study the effect of Amphetamine (AMPH), both an addictive and therapeutic drug on Dopamine (DA) release. We administer AMPH drug of high dosage 10mg/kg to an adult male Sprague-Dawley rat (∼350–400g) followed by electrical stimulation of DA neuron. The current corresponding...
The problem of identifying in advance the most effective treatment agent for various psychiatric conditions remains an elusive goal. To address this challenge, we propose a machine learning (ML) methodology to predict the response to a selective serotonin reuptake inhibitor (SSRI) medication in subjects suffering from major depressive disorder (MDD), using pre-treatment electroencephalograph (EEG)...
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