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Pharmacokinetics/pharmacodynamics models were designed and integrated into the BioGears® physiology engine to address the need for real time drug effects for varying patients and injury profiles. Ten drugs were validated using experimental and subject matter expert data. The plasma concentration curves had a good fit with experimental data and 48 of 50 physiologic parameters displayed a less than...
Remote and virtual labs represent a very important support in engineering teaching and can be used to improve the students learning process, for example of Biomedical Engineering courses, on topics such as the identification of models and control systems. This paper describes the demonstration of an online experiment, supported by a three-tank lab system, to model, simulate and monitoring a physiological...
Causes and impact of inter-subject variability in cellular electrophysiological behaviour are unknown. Understanding the effects of this variability is important, particularly as it can modulate response to drug application. Differences between individuals in response to drug action may be due to ionic-level differences, but the effects of these differences may be masked under normal physiological...
To observe effect of extracts from Root of Mirablis jalapa on Morphine Dependent mice. Mice of models and jasmine root extract were given morphine according a gradually increasing dose scheme, in which the morphine dose from 8 mg/ kg to 75 mg/ kg during 2 days. Mirablis jalapa extract groups use administration by gavage in the second day; normal group, models group use physiological saline intragastrically,...
We have built a collection of flexible, hepatomimetic, in silico components. Some are agent-based. We assemble them into devices that mimic aspects of anatomic structures and the behaviors of hepatic lobules (the primary functional unit of the liver) along with aspects of liver function. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers (IPRLs)...
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