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Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing protein 1 (EHD1)‐mediated lipid raft platforms, highly enriched in cholesterol, in the IL‐6 signalling...