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The development of new technologies to monitor drugs concentration directly in patient's blood is absolutely required to succeed in personalized drug therapies. In this study, Etoposide - a well-known anti-cancer drug - has been chosen as model for cyclic voltammetry detection of drugs. Carbon nanotubes are chosen as electron-transfer mediators to enhance the system sensitivity. A very low frequency...
A novel single-chip and multiplexed read-out circuit for multi-electrode electrochemical sensors, in standard 0.18 μm UMC CMOS technology, is presented. The circuit is a part of a fully-integrated biochip (in design) for the detection of multiple metabolites. The proposed topology is based on the potentiostat approach, and it is devoted to detect currents within the range of 250 pA 650...
CMOS-based sensor array chips for bio molecule detection provide high parallelism and further attractive features as compared to today's standard tools. They open the way to smart systems in medical and diagnostic applications. In this paper, a topical review is given concerning the basic operating principles of such arrays, transducer principles, related technical requirements and specifications,...
We use a planar, CMOS-based microelectrode array (MEA) featuring 3,150 metal electrodes per mm2 and 126 recording channels to record spatially highly resolved extracellular action potentials (EAPs) from Purkinje cells (PCs) in acute cerebellar slices. An Independent-Component-Analysis-based (ICA) spike sorter is used to reveal EAPs of single cells at subcellular resolution. Those EAPs are then used...
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