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Purpose of Review Controversy exists whether excess body fatness (measured by body mass index (BMI)) is associated with better cancer survival (“obesity paradox”). Here, we review the obesity paradox in cancer research and discuss potential explanations and future research directions. Recent Findings Overweight and obese cancer patients have better survival for diverse cancers. This apparent obesity...
A series of evidence demonstrated that obesity represents an established risk factor for an increase in the incidence of multiple cancer types and for poor cancer survival. Nevertheless, recent studies suggested that, in a series of cancers, patients with a normal body mass index (BMI) have worse outcomes than obese patients. This phenomenon, named ‘obesity paradox’ or ‘reverse epidemiology’ in cancer,...
Key Points • Mixed isomers of conjugated linoleic acid improved the lean body mass/adipose tissue ratio, decrease risk of cardiovascular disease, improve insulin sensitivity, and decrease risk and prevention of cancer in animal models. • Conjugated linoleic acid and its relationship with human body composition and with cancer do not corroborate the animal studies and thus, this natural or synthetic...
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