Neil E. Hubbard

article

Altered prolactin and androgen receptors expression in companion rat benign mammary tumours

Claire Vergneau‐Grosset, Caroline Cluzel, Guy Beauchamp, Neil E. Hubbard, more

Veterinary and Comparative Oncology > 19 > 2 > 213 - 221

Benign mammary tumours are among the most common tumours of companion rats (Rattus norvegicus domestica), as well as a major animal welfare concern and euthanasia. The first objective of this study was to evaluate the expression of oestrogen, progesterone, androgen, and prolactin receptors in neoplastic and normal mammary gland tissues and compare the expression of these receptors between groups....

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Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

Veronica D. Gonzalez, Nikolay Samusik, Tiffany J. Chen, Erica S. Savig, more

Cell Reports > 2018 > 22 > 7 > 1875-1888

We have performed an in-depth single-cell phenotypic characterization of high-grade serous ovarian cancer (HGSOC) by multiparametric mass cytometry (CyTOF). Using a CyTOF antibody panel to interrogate features of HGSOC biology, combined with unsupervised computational analysis, we identified noteworthy cell types co-occurring across the tumors. In addition to a dominant cell subset, each tumor harbored...

article

Pathobiology of the 129:Stat1^−/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

Hidetoshi Mori, Jane Q. Chen, Robert D. Cardiff, Zsófia Pénzváltó, more

Breast Cancer Research > 2017 > 19 > 1 > 1-18

Background Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1^tm1Rds) develop estrogen receptor-positive (ER⁺), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this model. In this report, we summarize details of the systemic and mammary pathology at preneoplastic and tumor-bearing...

chapter

Dietary Fat, Immunity, and Cancer

Kent L. Erickson, Darshan S. Kelley, Neil E. Hubbard

Nutrition and Health > Diet and Human Immune Function > Nutrition, Immunity, and Disease > 345-360

There are few data and a paucity of studies that have investigated the relationship among dietary fat, the immune system, and cancer in humans; few valid conclusions can be made from those studies. However, there have been some studies in patients with cancer where the addition of n-3 fatty acids to the diet have improved immune parameters and have lengthened survival (1, 2). For example, non-Hodgkin’s...

chapter

Alteration of Human Body Composition and Tumorigenesis by Isomers of Conjugated Linoleic Acid

Nirvair S. Kelley, Neil E. Hubbard, Kent L. Erickson

Nutrition and Health > Modern Dietary Fat Intakes in Disease Promotion > Dietary Fats > 121-131

Key Points • Mixed isomers of conjugated linoleic acid improved the lean body mass/adipose tissue ratio, decrease risk of cardiovascular disease, improve insulin sensitivity, and decrease risk and prevention of cancer in animal models. • Conjugated linoleic acid and its relationship with human body composition and with cancer do not corroborate the animal studies and thus, this natural or synthetic...

chapter

Conjugated Linoleic Acid and Cancer

Kent L. Erickson, Neil E. Hubbard, Alexander D. Borowsky, Patrizia Damonte

Nutrition and Health > Bioactive Compounds and Cancer > Role of Dietary Bioactive Components in Cancer Prevention and/or Treatment: Macroconstituents > 235-251

Key Points 1. Conjugated linoleic acid (CLA) contains conjugated double bonds and is known as a family of isomers of linoleic acid that can be found in the meat and dairy products. 2. In vitro studies have shown that CLA can inhibit the growth of mammary, colon, colorectal, gastric, prostate, and malignant liver cell lines and has also been shown to induce the expression of apoptotic genes...

chapter

Dietary Fat and Immunity in Humans

Kent L. Erickson, Darshan S. Kelley, Neil E. Hubbard

Handbook of Nutrition and Immunity > 141-152

article

CpG expedites regression of local and systemic tumors when combined with activatable nanodelivery

Azadeh Kheirolomoom, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, more

Journal of Controlled Release > 2015 > 220 > PA > 253-264

Ultrasonic activation of nanoparticles provides the opportunity to deliver a large fraction of the injected dose to insonified tumors and produce a complete local response. Here, we evaluate whether the local and systemic response to chemotherapy can be enhanced by combining such a therapy with locally-administered CpG as an immune adjuvant. In order to create stable, activatable particles, a complex...

article

Ultrasound molecular imaging of tumor angiogenesis with a neuropilin-1-targeted microbubble

Hua Zhang, Sarah Tam, Elizabeth S. Ingham, Lisa M. Mahakian, more

Biomaterials > 2015 > 56 > Complete > 104-113

Ultrasound molecular imaging has great potential to impact early disease diagnosis, evaluation of disease progression and the development of target-specific therapy. In this paper, two neuropilin-1 (NRP) targeted peptides, CRPPR and ATWLPPR, were conjugated onto the surface of lipid microbubbles (MBs) to evaluate molecular imaging of tumor angiogenesis in a breast cancer model. Development of a molecular...

article

Fatty acids and breast cancer: The role of stem cells

Kent L. Erickson, Neil E. Hubbard

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) > 2010 > 82 > 4-6 > 237-241

Studies with animal models in vivo as well as with animal and human tumor cells in vitro suggest that specific fatty acids could reduce breast tumorigenesis. The most striking dietary fatty acid studies in animal models that show promise for reduction of breast cancer risk in humans are with conjugated linoleic acids (CLA) and n-3 fatty acids. Although a number of mechanisms have been proposed, the...

article

Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein

Jung-Hyun Kim, Neil E. Hubbard, Vincent Ziboh, Kent L. Erickson

BBA - Molecular and Cell Biology of Lipids > 2005 > 1736 > 3 > 244-250

Conjugated linoleic acid (CLA) consists of a group of linoleic acid geometric isomers that have been shown to reduce tumor growth and metastasis in animal models of breast, prostate and colon cancer. To delineate a possible mechanism of action for CLA, we have recently shown that the 5-lipoxygenase product, 5-hydroxyeicosatetraenoic acid (5-HETE), could play a role in CLA alteration of mammary tumorigenesis...

article

Expression and regulation of murine macrophage angiopoietin-2

Neil E. Hubbard, Debora Lim, Mithia Mukutmoni, Ann Cai, more

Cellular Immunology > 2005 > 234 > 2 > 102-109

Our understanding of angiogenesis has increased significantly in the past few years with the discovery of angiopoietins (Ang). Specifically, Ang2 has been associated with pathologic as well as normal vascularization. While previous studies have shown that a major source of Ang2 has been endothelial cells and tumor cells, we reasoned that macrophages would also have the ability to express angiopoietins,...

article

Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid

Jung-Hyun Kim, Neil E. Hubbard, Vincent Ziboh, Kent L. Erickson

BBA - Molecular and Cell Biology of Lipids > 2005 > 1687 > 1-3 > 103-109

Conjugated linoleic acid (CLA) is a dietary fatty acid that has been shown to reduce tumorigenesis and metastasis in breast, prostate and colon cancer in animals. However, the mechanism of its action has not been clarified. The goal of this study was to determine whether CLA altered mouse mammary tumor cell growth and whether specific metabolites of the lipoxygenase pathway were involved in CLA action...

article

Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis

Neil E. Hubbard, Debora Lim, Kent L. Erickson

Cancer Letters > 2003 > 190 > 1 > 13-19

Recent studies have linked conjugated linoleic acid (CLA) to altered tumorigenesis of several sites. We showed recently that a mixture of CLA isomers was able to significantly decrease mammary tumor metastasis in mice. That effect was seen with as little as 0.1% CLA in the diet. Other studies with dietary CLA have shown that various isomers may have differential effects. The purpose of this work was...

article

Reduction of murine mammary tumor metastasis by conjugated linoleic acid

Neil E. Hubbard, Debora Lim, Lauri Summers, Kent L. Erickson

Cancer Letters > 2000 > 150 > 1 > 93-100

Recent studies have shown that conjugated linoleic acid (CLA) can inhibit the initiation and thus, incidence of mammary tumors in rodents. The concentration of CLA required for these effects was as low as 0.1% of the diet, with no increased effects above 1%. To date, there is little evidence that CLA has any effect on growth or metastasis of mammary tumors. In this report, we demonstrate that CLA,...

article

Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil

Mithia Mukutmoni-Norris, Neil E. Hubbard, Kent L. Erickson

Cancer Letters > 2000 > 150 > 1 > 101-109

We have previously shown that mice fed a high (n-3) fatty acid-containing diet with 20% (w/w) total fat had significantly slower mammary tumor growth, decreased numbers of metastatic pulmonary nodules, and decreased total metastatic load. In this study we sought to determine whether tumor vascularization was altered in mice fed diets varying in concentrations of (n-3) and (n-6) fatty acids. Several...

article

Sodium Butyrate Upregulates Kupffer Cell PGE2Production and Modulates Immune Function

Richard Perez, Frazier Stevenson, Jeremy Johnson, Murray Morgan, more

Journal of Surgical Research > 1998 > 78 > 1 > 1-6

The immunosuppressive effect of portal venous blood transfusions in organ transplantation has been well established and may be mediated by increased Kupffer cell production of the immunosuppressive arachidonic acid metabolite prostaglandin E ₂ (PGE ₂ ). In this study, butyrate, a short-chain fatty acid known to enhance gene transcription, is hypothesized to enhance Kupffer cell PGE...

article

Alteration of Platelet-Activating Factor-Induced Signal Transduction in Macrophages by n-3 Fatty Acids

Rabindranath Chakrabarti, Neil E. Hubbard, Debora Lim, Kent L. Erickson

Cellular Immunology > 1997 > 175 > 1 > 76-84

Diets rich in polyunsaturated n-3 fatty acids can alter various macrophage functions. One possible mechanism by which this occurs is through modulation of the physicochemical properties of the cell membrane and the signal transduction pathways associated with macrophage activation. In this study, we investigated how n-3 fatty acids altered the signaling pathway of the lipid-based mediator platelet-activating...

article

Dietary fish oil modulation of macrophagetumoricidal activity

Kent L. Erickson, Neil E. Hubbard

Nutrition > 1996 > 12 > 1 Supplement > S34-S38

Recent studies have shown that macrophages and their functions can be altered by dietary fat. Specifically, diets that are rich inn-3 fatty acids such as fish oils can have significant effects on macrophage cytolytic capacity and the production of select cytokines. The purpose of these studies was to characterize how dietary fish oils altered macrophage tumoricidal activity and the production of tumor...

article

Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function

Neil E. Hubbard, Kent L. Erickson

Cellular Immunology > 1995 > 160 > 1 > 115-122

Metabolites of arachidonic acid have been shown to be potent biological modulators of macrophage function. While the role of cyclooxygenase metabolites of arachidonic acid have been well studied, metabolites of lipoxygenase have not. In this report, we evaluate the role that select 5'-lipoxygenase (5'-LO) products may play in macrophage activation for select tumoricidal functions. When thioglycollate-elicited...

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Search results for: Neil E. Hubbard

Altered prolactin and androgen receptors expression in companion rat benign mammary tumours

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

Pathobiology of the 129:Stat1^−/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

Dietary Fat, Immunity, and Cancer

Alteration of Human Body Composition and Tumorigenesis by Isomers of Conjugated Linoleic Acid

Conjugated Linoleic Acid and Cancer

Dietary Fat and Immunity in Humans

CpG expedites regression of local and systemic tumors when combined with activatable nanodelivery

Ultrasound molecular imaging of tumor angiogenesis with a neuropilin-1-targeted microbubble

Fatty acids and breast cancer: The role of stem cells

Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein

Expression and regulation of murine macrophage angiopoietin-2

Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid

Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis

Reduction of murine mammary tumor metastasis by conjugated linoleic acid

Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil

Sodium Butyrate Upregulates Kupffer Cell PGE2Production and Modulates Immune Function

Alteration of Platelet-Activating Factor-Induced Signal Transduction in Macrophages by n-3 Fatty Acids

Dietary fish oil modulation of macrophagetumoricidal activity

Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function

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