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Episodic memories shape future behaviour and by aiding adaptive behaviour, are therefore important for survival in nature. Entorhinal cortex (EC)-hippocampal (HPC) networks have a crucial role in the formation of episodic memory, which consists of associations of space, objects, individuals and time. Neural circuits have been identified in the EC-HPC networks that provide spatial, contextual and object...
Recently, gene targeting and other mouse transgenic techniques have been used to study the cellular mechanisms underlying learning and memory mechanisms in the hippocampus. A key assumption of many of these studies is that lesions of the hippocampus have a similar impact on learning and memory in mice and in rats. Here, we used axon-sparing ibotenate lesions to determine whether damage to the hippocampus...
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