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In patients suffering from focal epilepsy, the region of seizure onset is characterized by hyperperfusion during the seizure (ictal state), and hypoperfusion in normal (inter-ictal) state. For diagnosis and surgery planning in epilepsy patients, ictal and inter-ictal SPECT images play a major role. However, comparison of this kind of data is a difficult clinical problem due to varying physiological...
Magnetic Resonance Imaging (MRI) provides various imaging modes to study the brain. We tested the benefits of joint analysis of multimodality MRI data using joint independent components analysis (jICA) in comparison to unimodality analyses. Specifically, we designed a jICA to decompose the joint distributions of multimodality MRI data across image voxels and subjects into independent components that...
Alignment of PET and CT images is essential for accurate measurements of cardiac perfusion. Misalignment can produce an erroneous attenuation map that projects lung attenuation parameters onto the heart wall, thereby underestimating the attenuation, and creating artifactual areas of hypoperfusion which may be misinterpreted as myocardial ischemia or infarction. The main cause of misregistration between...
Alzheimer's disease is a chronic degenerative disease of the central nervous system. Most common regional abnormalities for Alzheimer's disease are symmetric or asymmetric bilateral temporal or parietal hypoperfusion. Single-photon emission computed tomography (SPECT) is a useful tool in analyzing hypoperfusion in patients with Alzheimer's disease. The aim of this research is to provide a quantitatively...
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