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The partial volume effect (PVE) due to the low resolution of SPECT in brain SPECT volumes can be modeled as a convolution of a three-dimensional point-spread function (PSF) with the underlying true radioactivity. In this paper, a deconvolution guided by the edge locations in the geometric transfer matrix (GTM) method as a weighted regularization, denoted as RGTM, was proposed to take into account...
Brown adipose tissue (BAT) is a highly specialized thermogenic tissue and has profound effects on body weight, energy balance, and glucose metabolism. Body temperature regulation depends on the integrated activities of the autonomic nervous system, which is centered predominantly in the hypothalamus. The purpose of this study was to explore the interaction of brain and the activation of BAT by analyzing...
It is widely accepted and can be easily verified that any specific voxel in a class of brain single photon emission computed tomography (SPECT) volumes is of a univariate normal distribution. In this research, we conjecture that all the voxels in a class of SPECT volumes are also approximately of a multivariate normal (MVN) distribution from which in terms of the Bayes errors of statistics, an optimal...
In this paper, a characteristic-point-based fuzzy inference classifier (CPFIC) is proposed to perform two-class classification. Through fuzzy interpolation, a subset of classified samples can be taken as representatives of all samples. They are called characteristic points (CPs). A closeness matrix representing the closeness of two samples in a same class is proposed in selecting CPs. By solving a...
Alzheimer's disease is a chronic degenerative disease of the central nervous system. Most common regional abnormalities for Alzheimer's disease are symmetric or asymmetric bilateral temporal or parietal hypoperfusion. Single-photon emission computed tomography (SPECT) is a useful tool in analyzing hypoperfusion in patients with Alzheimer's disease. The aim of this research is to provide a quantitatively...
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