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Biomedical engineers at Imperial College London designed an intelligent insulin pump for diabetes patients. This biomimetic approach diverges from today's dominant method of delivering only insulin using a relatively simple control system. In a small clinical trial of 10 patients, they have been testing a device controlled by the microchip's cell models at two London hospitals. The device will infuse...
Steady-state electrohydrodynamic micropumping through bipolar conduction phenomenon has been investigated experimentally and numerically. A single-stage axisymmetric conduction micropump in the vertical configuration has been proposed in this paper. This micropump consists of four components: high voltage ring electrode, grounded disk-shaped electrode, insulator spacer, and inlet/outlet ports. The...
Progress toward a prototype MEMS gas chromatograph (muGC) designed for analyzing complex mixtures of volatile organic compounds (VOC) in breath is described. This muGC, named SPIRON, integrates a multi-stage preconcentrator/injector, a dual-microcolumn separation module, and a chemiresistor array detector with commercial minivalves and a minipump. Here, we describe results showing thermal control...
This paper presents the integration of the fabrication processes for an implantable multi-analyte biochip system. The implantable biochip system has a microfluidic channel in which an electrochemical biosensor and a dielectrophoresis (DEP) micropump are fabricated by surface micromachining. The enzyme-based biosensor consists of three electrodes and detects the glucose level instantaneously by utilizing...
We report (1) the integration of the first functioning MEMS gas chromatography system ( muGC) featuring a micropump, a micro-column, and a micro-chemiresistor sensor array; and (2) experimental demonstration of the state-of-the-art multi-vapor gas separation and detection. In particular, we report the best GC analysis data from the first micropump-driven muGC system to date: the separation and detection...
Through studying the micropump and microvalve used in microfluidic control chemical analysis from the design of structure, working principle and fabrication process, a novel PZT-driven micropump was developed. The construction and the fabrication process are quite simple. It consists of flexible PDMS pump diaphragm, base plate and piezo-bimorph actuator. Diaphragm, meanwhile, is an active valve whose...
In this paper, we have investigated the characteristics of a thermopneumatic-actuated polydimethylsiloxane (PDMS) microfluidic system integrated with a micropump and microvalves on the same structure. A thermopneumatic-actuated PDMS microfluidic system has been fabricated and its properties are characterized. The advantages of proposed microfluidic system are disposable, low cost fabrication process...
We have developed an integrated dynamic lens system for in vivo optical imaging. Bioinspired dynamic microfluidic lenses allow for real-time dynamic manipulation of the lens focal length via microfluidic injection into a PDMS membrane-capped chamber. A piezoelectrically actuated micropump is integrated with with the lens to provide highspeed, accurate lens tunability. The 5mm dynamic lens has demonstrated...
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