Serwis Infona wykorzystuje pliki cookies (ciasteczka). Są to wartości tekstowe, zapamiętywane przez przeglądarkę na urządzeniu użytkownika. Nasz serwis ma dostęp do tych wartości oraz wykorzystuje je do zapamiętania danych dotyczących użytkownika, takich jak np. ustawienia (typu widok ekranu, wybór języka interfejsu), zapamiętanie zalogowania. Korzystanie z serwisu Infona oznacza zgodę na zapis informacji i ich wykorzystanie dla celów korzytania z serwisu. Więcej informacji można znaleźć w Polityce prywatności oraz Regulaminie serwisu. Zamknięcie tego okienka potwierdza zapoznanie się z informacją o plikach cookies, akceptację polityki prywatności i regulaminu oraz sposobu wykorzystywania plików cookies w serwisie. Możesz zmienić ustawienia obsługi cookies w swojej przeglądarce.
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits,...
Recent experiments have shown that transverse relaxation (TR) T2-based in vivo oxygen electron paramagnetic resonance imaging results are confounded by the effects of additional relaxation mechanisms. On the contrary, spin-lattice relaxation (SLR) T1-based oxymetry is more precise and nearly free from those interfering mechanisms. In this article we study the differences between TR and SLR in vivo...
An explosion of new research is vastly changing the medical sciences understanding of the cancer biology and giving new clues about how to attack it. This research tries to use a new impact analysis approach to investigating how the age, year and sex affect the probability of getting breast cancer. The impact analysis is an approach that is used to investigate the association of the impact factor...
The aim of this paper is to present a two-dimensional simulation tool based on several mathematical models, visualizing the growth and development of a solid tumour in avascular growth phase, vascular growth phase and the progress of angiogenesis. The avascular tumour remains in a diffusion-limited state of a few millimeters in diameter, while during vascularized phase, tumour cell proliferating rapidly...
We present a study of the spatial variation of nuclear morphology of stromal and cancer-associated fibroblasts in the mouse mammary gland. The work is part of a framework being developed for the analysis of the tumor microenvironment in breast cancer. Recent research has uncovered the role of stromal cells in promoting tumor growth and progression. In specific, studies have indicated that stromal...
Microarray technology and high-throughput proteomics have revolutionized cancer biology by generating vast amount of data for various cancers. To gain insights into the biological processes that drive breast cancer recurrence, we integrate gene expression profiles of breast cancer and protein interaction networks in search for affected regulatory and signaling networks statistically associated with...
This paper presents a study of possible extensions of pathway logic to represent and reason about semiquantitative and probabilistic aspects of biological processes. The underlying theme is the annotation of reaction rules with affinity information that can be used in different simulation strategies. Several such strategies were implemented, and experiments carried out to test feasibility, and to...
Luciferases are light-emitting enzymes that have been used as reporters of biological function for several decades, and have more recently been used as reporters for the study of biological processes in living animals. Although these enzymes appear to have evolved independently in different species, they are all oxygenases that require energy, a chemical substrate, and oxygen. The technologies of...
Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.