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It is well documented that glucocorticoids are potent anti-inflammatory and immunosuppressive agents that are known to affect cell mediated inflammation by the inhibition of cellular proliferation and cytokine production. The literature is lacking knowledge in elucidating the mode of action of such agents on the transformed like cells in culture. Therefore, RAW (macrophage like) cells was selected...
Objective: To understand the research hotspots of C-reactive protein by PubMed. Methods: With MS Excel, SPSS, Cytoscape software, we took MeSH (Medical Subject Headings) word frequency analysis, clustering analysis, co-word network graph of PubMed papers. Results: It shows that the current C-reactive protein research hotspots had focus on "Inflammation, Cardiovascular Diseases, Biological Markers,...
Capsule endoscopy represents a highly convenient but limited means of imaging inflammatory conditions of the small bowel. The inclusion of high frequency microultrasound into a capsule endoscope has the potential to enhance diagnostic capabilities with subsurface imaging of the bowel wall. Experimental studies on abattoir-obtained porcine small bowel have been carried out as an ethical means to characterize...
The authors developed a mathematical model of arachidonic acid (AA) degradation to prostaglandins (PGs) and leukotrienes (LTs), which are implicated in the processes of inflammation and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs). The model focuses on two PGs (PGE2 and PGD2) and one LT (LTC4), their % increases and their ratios. Results are compared with experimental studies...
Colon cancer and precancerous colon lesions are major health problems. The most frequent precancerous cancer lesions are polyps characterized by abnormal tissue growth in the human bowel. There are also anomalies such as inflammation and bleeding area. Colon capsule endoscopy (CCE) is a recent promising technology which enables to obtain videos of the inside of the intestine via an on board digital...
Temperature difference in the skin surface reflects the abnormality present in the human body. Considering the phenomenon, detection and forecasting the change of temperature is the principal objective of using Medical Infrared Thermography (MIT) as a diagnostic tool for inflammatory pain diseases. Medical Infrared Thermography (MIT) is a non-invasive, non-contact and fast imaging technique that record...
Patch-based transdermal drug delivery technology offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections related to issues such as patient acceptability and injection safety. In this study, we developed a flexible and disposable microneedle-fluidic-system (MFS) which can achieve finger driven on-chip drug loading and delivery functions by integrating Polydimethylsiloxane...
Neutrophils play an important role against bacterial infection, mainly methicillin resistant Staphylococcus aureus (MRSA). Therefore, we developed an animal model to simultaneously monitor bacterial colonization and neutrophil migration in vivo. Using lys-EGFP C57BL/6 mice, we initially rendered the mice temporally neutropenic using cyclophosphamide (CPM) treatment (300mg/kg or 375mg/kg). Later, bioluminescent...
Wrist pulse signal is believed to contain critical information of the patients' health condition. This project aims to analyze the time series wrist pulse signals in order to distinguish patients suffering from various symptoms with healthy people. In this paper, the four inflammation symptoms tackled in this project are Appendicitis (A), Acute Appendicitis (AA), Pancreatitis (P) and Duodenal Bulb...
One of the major causes of lameness in intensive dairy goat farms is claws' overgrowth and deformation. These problems are thought to be painful but more studies are needed to assess the degree and extension of pain. The demand for more objective ways to assess pain is growing. Infrared thermography may be one of them. In our study ninety four dairy goats from the same pen were classified for claw...
The emergence of organs-on-a-chip microfabricated devices and integrated microphysiological systems has facilitated study of human physiology in an organ-specific context, enabling the development and validation of predictive models relevant in drug discovery. Quantitative investigations of cytokine profiles and signaling networks across a range of physiological perturbations, in a highly multiplexed...
Analyzing the hidden information from the images are helpful to identify the various causes. In general processing of images includes Pre-processing, segmentation, Feature extraction and Classification. Significance of classifier is essential since results are always based on the classifier. The ultimate aim is to explain how WEKA tool is used for rheumatoid arthritis and investigate the performance...
Atherosclerosis is the underlying pathology behind cardiovascular disease, the main cause of death in worldwide. Inflammation plays a pivotal role in its pathogenesis. Tocotrienol is a palm derived vitamin E component, known have potent anti-inflammatory properties. The effect of tocotrienol on formation and progression of atherosclerosis is unknown. Aim: to determine the anti-inflammatory and anti-atherosclerotic...
Alzheimer's disease (AD) is currently the most common form of dementia affecting the elderly, and its occurrence rate is only expected to increase over the next several decades. Though there is a vast array of knowledge about individual molecules and genetics involved with the disease, there is no clear understanding of the mechanism of pathogenesis. To help better understand the disease process,...
"Diabesin" is a term to describe concomitant morbid conditions of diabetes, obesity, and inflammation. Here we have performed in silico analyses of 24 (twenty four) human genes, known to undergo genomie imprinting, in order to choose potential genetic variants that might be associated to diabesin susceptibility. Our preliminary results indicate that potential diabesin risk haplotypes are...
This paper will present a method for disseminating mobile agents throughout a network in order to protect that network. This method is based on the immune concept of inflammation, which provides greater blood flow to areas of the body in danger. It also presents a prototype implementation of the model, and analyses that prototype.
Prostaglandin E2 (PGE2) has a crucial role in inflammation and is synthesized by cyclooxygenase-2 (COX-2), of which the expression is induced in inflammatory site by inflammatory stimuli like lipopolysaccharide (LPS). In the present study, nine flavonoids were tested for their effects on prostaglandin E2 production and cyclooxygenase-2 expression in LPS-stimulated RAW 264.7 macrophages. All the nine...
Biomedical applications of thermography has been increased over the past fifty years. As it is completely non-invasive technique its use has been useful in the medical research as sensitive diagnostic method for different clinical and experimental levels. Thermography gives us valuable information about temperature differences of different parts of a human skin. Thus nervous system, metabolic or vascular...
Clinical symptoms of gastrointestinal (GI) infections are often caused by the inflammatory response elicited to eliminate the invading microbe. Here we present ENISI, a simulator of GI immune mechanisms in response to resident commensal bacteria as well as invading pathogens and the effect on host clinical symptoms. ENISI is a tool for identifying treatment strategies that reduce inflammation-induced...
The signal peptide of eosinophil cationic protein (ECPsp) is known to play an important role in translocating ECP to extracellular space. However, we previously discovered that ECPsp has a novel function of inhibiting microbial growth and regulating the gene expression of tumor growth factor-alpha (TGF-α) and epidermal growth factor receptor (EGFR) in mammalian cells. In the present study, we first...
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