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Introduction Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, with high associated costs. Most of the cost burden results from acute exacerbations of COPD (AE-COPD), events associated with heightened symptoms and mortality. Cellular mechanisms underlying AE-COPD are poorly understood, likely because they arise from dysregulation of complex immune...
The emergence of organs-on-a-chip microfabricated devices and integrated microphysiological systems has facilitated study of human physiology in an organ-specific context, enabling the development and validation of predictive models relevant in drug discovery. Quantitative investigations of cytokine profiles and signaling networks across a range of physiological perturbations, in a highly multiplexed...
Due to the inherent complexities involved in understanding a redundant, non-linear process like inflammation, systems biology modeling approaches have been proposed. While these models have produced encouraging results, they do not take into account the circadian nature of many of their components. Circadian rhythms are daily variations in a wide number of biological processes, including many of the...
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