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It is well documented that glucocorticoids are potent anti-inflammatory and immunosuppressive agents that are known to affect cell mediated inflammation by the inhibition of cellular proliferation and cytokine production. The literature is lacking knowledge in elucidating the mode of action of such agents on the transformed like cells in culture. Therefore, RAW (macrophage like) cells was selected...
The emergence of organs-on-a-chip microfabricated devices and integrated microphysiological systems has facilitated study of human physiology in an organ-specific context, enabling the development and validation of predictive models relevant in drug discovery. Quantitative investigations of cytokine profiles and signaling networks across a range of physiological perturbations, in a highly multiplexed...
Obesity is the final consequence of a chronic positive energy balance in adipocytes,and it is a major risk factor for insulin resistance,type 2 diabetes mellitus,and many other lifestyle-related diseases.Adipose tissue can sense the energy status and signals other organs with adipokines.Insulin resistance is closely associated with inflammatory adipokines and oxidative stress in adipose tissue. However,...
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