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Peripheral nerve regeneration is limited by lack of growth permissive microenvironment and glial scarring. An ideal biomaterial for regeneration should support neurons and non-neural cells of Schwann cells and endothelial cells. Numerous tissue engineered strategies have been proposed for PNS regeneration but only a few approaches look at the role of support cells and microenvironment. It is therefore...
Here we demonstrate proof-of-concept for controlling cardiac fibroblast collagen secretion on a microfabricated poly(glycerol sebacate) scaffold by endocardial endothelial cells.
The good seed cells were the key component of cartilage tissue engineering. Because of their own advantages, mesenchymal stem cells (MSCs) became a good choice of seed cells in cartilage tissue engineering field. However, how to regulate MSCs to directly differentiate into chondrocytes was one of the difficulties at present. Sox9 and Cbfa1 were two important transcription factors for chondrogenic...
Bone exhibits hierarchical levels of organization from macroscopic to microscopic, and nano- length scales. Furthermore, multiple bioactive peptides, as part of the collagenous and non-collagenous water soluble glycoproteins and proteoglycans in the bone ECM, interact with progenitor BMS cells to initiate the cascade of chemotaxis, differentiation, and mineralization. In this work, a nanofiber hydrogel/apatite...
Engineered muscle tissue offers a promising solution for the treatment of large muscle defects. Three-dimensional tissue engineered matrices, such as collagen microthreads can be used to grow new myofibers that will reduce scar formation and integrate easily into native myofibers. A culture system that would allow efficient seeding of cells onto engineered 3D matrices is not available. Self assembled...
In this study, we compared experimentally measured fiber network kinematics and the macroscopic mechanical response from cell-compacted, cross-shaped collagen gels (cruciforms), with the predictions from our multiscale modeling technique. The macroscopic finite element model matched the physical dimensions and boundary conditions of the experimental cruciform to be modeled. Different microscale network...
Our lab has used an optical coherence microscope (OCM) to assess both the structure of tissue-engineered corneal constructs and their transparency. Currently, we are not able to resolve cells versus collagen matrix material in the images produced. We would like to distinguish cells in order to determine if they are viable while growing in culture and also if they are significantly contributing to...
A transparent artificial cornea derived from biological material is the ultimate goal of corneal research. Attempts at artificial corneal constructs produced from synthetic polymers have proved unsuccessful due to lack of biocompatibility and ability to integrate into the tissue. We have designed a corneal model derived from collagenous biological materials that has several advantages: it has low...
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