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In cancer research, the use of antisense oligonucleotide molecular beacons, able to generate a fluorescent signal when they hybridize with their target mRNA, may represent an innovative strategy that conjugates the ability of sensing specific mRNA with the pharmacological silencing activity, preventing the overexpression of proteins associated to cancer development. In cancer context, this approach...
To observe the effects of urotensinII on renal fibrosis and its mechanism. The renal interstitial fibrosis model were induced by unilateral ureteral obstruction (UUO) in rats, and the rat renal interstitium fibroblasts (NRK-49F) were used for in vitro mechanism study. Results showed that expression of UII and UT was significantly upregulated at both mRNA and protein levels in the UUO group compared...
Here we demonstrate proof-of-concept for controlling cardiac fibroblast collagen secretion on a microfabricated poly(glycerol sebacate) scaffold by endocardial endothelial cells.
We extend multiphoton microscopy to study the collagen remodeling and transplanted autologous fibroblasts metabolic states in mouse dermis after cellular injection.
Engineered muscle tissue offers a promising solution for the treatment of large muscle defects. Three-dimensional tissue engineered matrices, such as collagen microthreads can be used to grow new myofibers that will reduce scar formation and integrate easily into native myofibers. A culture system that would allow efficient seeding of cells onto engineered 3D matrices is not available. Self assembled...
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