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Duhuo-Jisheng-Tang is a Chinese herbal formula designed to treat rheumatoid arthritis (RA) with syndrome dual deficiency of liver and kidney. Although its therapeutic clinical effect is widely accepted over one thousand years, its therapeutic agents are still obscure. In this study, we explored the potential therapeutic agents of Duhuo-Jisheng-Tang for RA by integrating leading knowledge databases...
Fang-Feng-Tang is a Chinese herbal formula which is designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although its therapeutic effects are widely accepted, its mechanism is still obscure. In this study, by integrating leading knowledge databases of associated different domains, we explored Fang-Feng-Tang's potential therapeutic agents for RA through targeted pathway hierarchies...
Da-Fang-Feng-Tang is a Chinese herbal formula designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although it's clinical effect have been accepted through 1000 years' clinical practises, its molecule mechanism is still obscure. In this study, by integrating powerful knowledge databases, though bioinformatics analysis, we explored the potential molecular mechanism of Da-Fang-Feng-Tang...
Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. Traditional Chinese medicine (TCM) treats RA with herbal formulae according to different syndrome/pattern classification. One important syndrome/pattern in RA is Feng-Han-Shi-Bi. Targeting this syndrome,...
To analyze the component law of Chinese medicines for rheumatoid arthritis, and develop new prescriptions for rheumatoid arthritis through mutual Information mining methods. Chinese medicine recipes for rheumatoid arthritis were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified...
Rheumatoid arthritis (RA) is a chronic disease that affects the joints, often those in a person's wrists, fingers, and feet. In contrast to FDA-approved anti-RA drugs, Tripterygium wilfordii Hook F (TwHF), a traditional Chinese medicine (TCM), featured as multi-targeting, have been acknowledged with notable anti-RA effects although the pharmacology is unclear. In this work, we investigated the therapeutic...
In this paper an assay for the detection of genes associated with rheumatoid arthritis (RA) and multiple sclerosis, using polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOP) is presented, in order to be further applied in a portable Lab-On-Chip (LOC) device. A substantial part of these reagents were based on the literature (11th International Histocompatibility Workshop,...
We combine text mining with methods of systems biology for the first time, to predict functional networks for therapeutic mechanisms of Traditional Chinese Medicine in rheumatoid arthritis. The text mining results indicated rheumatoid arthritis highly associated with Tripterygium wilfordii, and eleven genes associated with both. Protein interaction information for these genes from databases and Literature...
The purpose of this research is to discover valuable medical facts by mining TKA (total knee arthroplasty) surgical volume of three different hospital levels from Taiwan NHI (National Health Insurance) database. In this paper, there are three main objectives provided: (1) to build up the learning curves using the patients?? outcomes of three different hospital levels; (2) to characterize whether TKA...
In this study, we developed a systematic method to find risk alleles and relative gene for rheumatoid arthritis (RA). The method consists of three steps: 1) genome-wide case-control association studying based on haplotypes; 2) genome-wide association mapping based on directly mining haplotypes produced from case-control data via a density-based clustering algorithm; 3) candidate genes within 1 Mb...
The traditional healthcare system is characterized by hospital or clinic-based face-to-face contacts between the patient and care provides, which frequently occur at times and locations that are inconvenient or difficult for the patient. The healthcare delivery in the future needs to be provided in a distributed, patient-centered manner. The distributed diagnosis and home healthcare (D2H2) will benefit...
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