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Chemotherapy is the main strategy in the treatment of cancer; however, the development of drug-resistance is the obstacle in long-term treatment of cervical cancer. Cisplatin is one of the most common drugs used in cancer therapy. Recently, accumulating evidence suggests that miRNAs are involved in various bioactivities in oncogenesis. It is not unexpected that miRNAs play a key role in acquiring...
The occurrence of cellular drug resistance to cytotoxic drugs at the clinical level called multidrug resistance (MDR) has been studied by many research groups. Drug resistance is a major problem in chemotherapy for cancer. One of the most important reasons for this resistance is the over-expression of the multiple drug resistance (mdr) gene before and after induction of chemotherapy. It is frequently...
Objective: To evaluate the clinical efficacy and safety of cytokine-induced killer (CIK) cells immunotherapy in combination with platinum chemotherapy and Xiaoji decoction in patients with advanced stage non-small cell lung cancer (NSCLC). Methods: Patients with advanced stage NSCLC were randomly assigned to Group A (platinum chemotherapy plus xiaoji decoction) and Group B (platinum chemotherapy plus...
Cell mechanics are correlated with cell functions, and are regarded as an effective biomarker indicating onset and progression of diseases. Chronic myeloid leukemia (CML) is defined as a myeloproliferative disorder, expressed as increased proliferation of the granulocytic cells in blood and bone marrow. Chemotherapy drug resistance is a major obstacle to the treatment of CML. However, information...
This study deals with the planning of anti-cancer therapy in mice with drug-resistance using mathematical modeling and optimal control. By making use of experimental data in order to develop our mathematical models, we herein propose a promising methodology by which cancer progression in mice with resistance to docetaxel, a widely-used anti-cancer drug, can be controlled. We leverage experimental...
Malignant glioma, the most common type of primary central nervous system (CNS) cancer, has consistently proven unresponsive to chemotherapy. This is due partly to the physiological barriers in place to protect the brain from outside infection and partly due to the changes in gene expression that typify pathogenesis in glioma. One example of such a change in gene expression is the constitutive activation...
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