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The efficacy of anticancer therapies cannot be assessed easily during the treatment yet it is an important determinant of eventual treatment success. It has been observed that ultrasound backscatter from collections of acute myeloid leukaemia cells that are undergoing cell death due to chemo- or radiation therapy show increased intensity and changes in spectral characteristics. However, similar experiments...
A novel four-dimensional, patient-specific Monte Carlo simulation model of solid tumor response to chemotherapeutic treatment in vivo is presented. The special case of glioblastoma multiforme treated by temozolomide is addressed as a simulation paradigm. Nevertheless, a considerable number of the involved algorithms are generally applicable. The model is based on the patient's imaging, histopathologic...
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