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Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen (HLA) gene has been established to be involved in the susceptibility to HD. We aim to investigate the associations between HLA‐B alleles and Han Chinese children with HD by both case‐control and family‐based studies. A total of 108 unrelated...
Donor human leukocyte antigen (HLA)‐specific antibodies (Abs) with the ability to activate complement are associated with an increased risk of early Ab‐mediated rejection (AMR) of kidney allografts. In recent years, also non‐HLA Abs‐binding endothelial cells have been shown to elicit early AMR. Donor‐specific anti‐endothelial cell Abs escape detection in the pre‐transplant evaluation if only lymphocytes...
The chemokine receptor [C–C chemokine receptor 5 (CCR5)] is expressed on diverse immune effecter cells and has been implicated in the pathogenesis of rheumatoid arthritis (RA). This study sought to determine whether single‐nucleotide polymorphisms (SNPs) in the CCR5 gene and their haplotypes were associated with susceptibility to and severity of RA. Three hundred fifty‐seven patients with RA and 383...
The human leukocyte antigen (HLA)‐A*24:96 allele differs from the closest matching allele A*24:01:01:01 by three nucleotide substitutions in exon 3 at nt 411(C‐>T), nt 412(C‐>A) and nt 419(A‐>T).
The newly detected HLA‐DPB1*136:01 is distinguished from HLA‐DPB1*69:01 by a single‐nucleotide exchange at position 258, resulting in a coding change 57D‐‐>57E .
Distinct human leukocyte antigen (HLA) allele and haplotype distributions occur in the northern and southern Han populations of China. However, different ethnic groups in China show limited regional distributions for many HLA alleles and haplotypes. Therefore, it is necessary and meaningful to study the differences in HLA allele and haplotype distribution for northern and southern ethnic groups of...
Although the role of CD14 in recognizing Mycobacterium tuberculosis is well‐understood, the possible role of polymorphisms in susceptibility to develop tuberculosis remains unclear. This study evaluates whether there is an association of polymorphisms within the promoter of the CD14 gene with susceptibility to pulmonary tuberculosis. In a case–control study, we genotyped the eight known single nucleotide...
To investigate the relationship between human leukocyte antigen (HLA) class I and II alleles and treatment‐induced anemia in chronic hepatitis C (CHC) patients receiving combination therapy with pegylated interferon‐α (PEG‐IFN‐α) and ribavirin (RBV). One hundred six naïve CHC patients (59 females and 47 males; mean age, 53.08 years) who underwent combination treatment were enrolled. The patients were...
Human leukocyte antigens (HLA) are important genetic markers of tissue identity and accurately reflect ancestral history. The work reported in this paper provides a detailed description of HLA polymorphism in Polynesian and Maori individuals in relation to other populations. Our study concerns HLA classes I and II antigens in Polynesian (N = 36) and Maori (N = 114) subjects genotyped at two digit...
We previously reported the development of genomic‐DNA‐based high‐resolution genotyping methods for SLA‐DQB1 and DRB1. Here, we report the successful typing of SLA‐DQA using similar methodological principles. We designed a method for comprehensive genotyping of SLA‐DQA using intronic sequence information of SLA‐DQA exon 2 that we had obtained from 12 animals with different SLA‐DQB1 genotypes. We expanded...
Two novel HLA‐B alleles were characterized. HLA‐B*37:34 shows two nucleotide differences regarding B*37:10 at codons 79 (CGC>CGG) and 80 (ACC>ATC), resulting in one amino acid replacement at position 80 (T>I). HLA‐B*44:152 differs from B*44:02:01 in one nucleotide at codon 81 (GCG>ACG) giving rise to a leucine to threonine substitution at position 81.
Homozygosity for a nonsense mutation in the fucosyltransferase 2 (FUT2) gene (rs601338G>A) leads to the absence of ABH blood groups (FUT2 non‐secretor status) in body fluids. As the secretor status has been shown to be a major determinant for the gut microbial spectrum, assumed to be important in the gut immune homeostasis, we studied the association of rs601338‐FUT2 with celiac disease (CelD)...
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