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IntroductionSerotonin 5‐HT1A receptors have been investigated in various CNS disorders, including epilepsy, mood disorders, and neurodegeneration. [18F]Mefway (N‐{2‐[4‐(2′‐methoxyphenyl)piperazinyl]ethyl}‐N‐(2‐pyridyl)‐N‐(cis/trans−4′‐[18F]fluoromethylcyclohexane)‐carboxamide) has been developed as a suitable positron emission tomography (PET) imaging agent for these receptors. We have now evaluated...
We have recently demonstrated that, in C57/Bl6 mice, long‐term voluntary wheel running is anxiogenic, and focal hippocampal irradiation prevents the increase in anxiety‐like behaviors and neurobiological changes in the hippocampus induced by wheel running. Evidence supports a role of hippocampal 5‐HT1A receptors in anxiety. Therefore, we investigated hippocampal binding and function of 5‐HT1A receptors...
Electroconvulsive therapy (ECT) treats depression by repeated administration of seizure‐inducing electrical stimuli. To assess the effects of repeated electroconvulsive shocks (ECSs), an animal model of ECT on monoamine transmission, Sprague–Dawley rats were administered 6 ECS over 2 weeks and in vivo single‐unit extracellular electrophysiological recordings were obtained 48 h after the final ECS...
Oscillations in brain activities with periods of minutes to hours may be critical for normal mood behaviors. Ultradian (faster than circadian) rhythms of mood behaviors and associated central nervous system activities are altered in depression. Recent data suggest that ultradian rhythms in serotonin (5HT) function also change in depression. In two separate studies, 5HT metabolites in cerebrospinal...
Preclinical models suggest that repeated high‐dose methamphetamine (METH) exposures, administered in a “binge‐like” pattern, acutely decrease norepinephrine (NE), and acutely and persistently decrease serotonin (5‐hydroxytryptamine; 5HT) content in the frontal cortex. However, the impact of METH self‐administration on this region is unknown. Because of the importance of the monoaminergic neurons in...
Estradiol (E) and progesterone (P) promote spinogenesis in several brain areas. Intracellular signaling cascades that promote spinogenesis involve RhoGTPases, glutamate signaling and synapse assembly. We found that in serotonin neurons, E ± P administration increases (a) gene and protein expression of RhoGTPases, (b) gene expression of glutamate receptors, and (c) gene expression of pivotal synapse...
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