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We have developed 18F‐trans‐Mefway (18F‐Mefway) for positron emission tomography (PET) imaging studies of serotonin 5‐HT1A receptors which are implicated in various brain functions. Translation of imaging the 5‐HT1A receptor in animal models to humans will facilitate an understanding of the role of the receptor in human brain disorders. We report comparative brain distribution of 18F‐Mefway in normal...
IntroductionSerotonin 5‐HT1A receptors have been investigated in various CNS disorders, including epilepsy, mood disorders, and neurodegeneration. [18F]Mefway (N‐{2‐[4‐(2′‐methoxyphenyl)piperazinyl]ethyl}‐N‐(2‐pyridyl)‐N‐(cis/trans−4′‐[18F]fluoromethylcyclohexane)‐carboxamide) has been developed as a suitable positron emission tomography (PET) imaging agent for these receptors. We have now evaluated...
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