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Ca2+‐dependent adhesion molecules, cadherins, localised at synaptic sites are critically involved in long‐term potentiation (LTP). N‐cadherin is thought to promote LTP whereas cadherin‐11 seems to counteract LTP. Since high synaptic activity is accompanied by local transient changes of the pH in the synaptic cleft, we studied whether the binding activity of cadherins is dependent on the pH and whether...
Variations in the expression levels of the dopamine transporter (DAT) can influence responsiveness to psychostimulant drugs like cocaine. To better understand this relationship, we studied a new DAT‐low expresser (DAT‐LE) mouse model and performed behavioral and biochemical studies with it. Immunoblotting and [3H]WIN 35,428 binding analyses revealed that these mice express ∼35% of wildtype (WT) mouse...
Acellular nerve allografts (ANA) possess bioactivity and neurite promoting factors in nerve tissue engineering. Previously we reported that low dose ultrashort wave (USW) radiation could enhance the rate and quality of peripheral nerve regeneration with ANA repairing sciatic nerve defects. Meanwhile, ANA implanted with bone marrow stromal cells (BMSCs) exhibited a similar result. Thus, it is interesting...
We have recently demonstrated that, in C57/Bl6 mice, long‐term voluntary wheel running is anxiogenic, and focal hippocampal irradiation prevents the increase in anxiety‐like behaviors and neurobiological changes in the hippocampus induced by wheel running. Evidence supports a role of hippocampal 5‐HT1A receptors in anxiety. Therefore, we investigated hippocampal binding and function of 5‐HT1A receptors...
Within the amygdala, AMPA receptors expressing the AMPA‐GluR1 (GluR1) subunit play an important role in basal glutamate signaling as well as behaviors associated with exposure to drugs of abuse like opiates. Although the ultrastructural location of GluR1 is an important functional feature of this protein, the basal distribution of GluR1, as well as its sensitivity to acute morphine, has never been...
N‐[(4‐trifluoromethyl) benzyl] 4‐methoxybutyramide (GET73) is a newly synthesized compound displaying anti‐alcohol and anxiolytic properties. In light of the importance of the hippocampal CA1 subregion in alcohol addiction and anxiety‐like behaviors—this in vivo microdialysis study characterized the effect of GET73 on extracellular GABA levels in the hippocampal CA1 region of the freely moving rat—including...
Both pre‐ and post‐synaptic effects of trace amines have been demonstrated. The putative intracellular location of Trace Amine‐Associated Receptors necessitate that membrane transport processes be present in order for post‐synaptic effects to occur. Here we examine the ability of trace amines to cross synthetic (Fluorosomes) and native (synaptosomes) lipid bilayer membranes. Trace amines readily crossed...
Electroconvulsive therapy (ECT) treats depression by repeated administration of seizure‐inducing electrical stimuli. To assess the effects of repeated electroconvulsive shocks (ECSs), an animal model of ECT on monoamine transmission, Sprague–Dawley rats were administered 6 ECS over 2 weeks and in vivo single‐unit extracellular electrophysiological recordings were obtained 48 h after the final ECS...
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