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Background: Kv7.5 (KCNQ5) channels conduct M‐type potassium currents in the brain, are expressed in skeletal muscle, and contribute to vascular muscle tone. Methods: We coexpressed Kv7.5 and KCNE1–3 peptides in HEK293 cells and then analyzed their association using electrophysiology and co‐immunoprecipitation, assessed localization using confocal microscopy, examined targeting of the oligomeric channels...
Introduction: The neurotoxic side effects of oxaliplatin (a reference drug in the treatment of digestive tract tumors) can force suspension of treatment. The mechanisms of neuropathy are unclear. We aimed to simulate oxaliplatin‐induced hyperactivity in myelinated axons (MA) based on published experimental data. Methods: A Hodgkin–Huxley‐type multi‐cable MA model was used, which took into account...
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