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The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β‐adrenergic function. Our data demonstrate that DMPK knockout mice present altered β‐agonist–induced responses and suggest that this...
Introduction:Widespread musculoskeletal pain is a well‐known symptom of myotonic dystrophy type 2 (DM2), but so far it has been addressed in only a few studies.
Methods:A postal survey for all traceable DM2 patients (n = 132) was conducted. A specific questionnaire, and severity and interference subscales of the Brief Pain Inventory, quality of life (RAND‐36), and modified Beck Depression Inventory...
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