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Gene compensation by members of the myogenic regulatory factor (MRF) family has been proposed to explain the apparent normal adult phenotype of MyoD−/− mice. Nerve and field stimulation were used to investigate contraction properties of muscle from MyoD−/− mice, and molecular approaches were used to investigate satellite‐cell behavior. We demonstrate that MyoD deletion results in major alterations...
Autoantibodies to muscle‐specific kinase (MuSK) can cause myasthenia gravis (MG). The pathophysiological mechanism remains unknown. We report in vitro electrophysiological and histological studies of the neuromuscular junction in a MuSK MG patient. Low levels of presynaptic acetylcholine release and small miniature endplate potentials were found. This combination of pre‐ and postsynaptic abnormalities...
Endplate‐targeted botulinum toxin injections can achieve optimal neuromuscular blockade. The goal of this study was to identify the motor endplate (MEP) zone in the human psoas muscle through dissection. In 24 human cadaver psoas muscles the nerve branches and their intramuscular course were followed by stereoscopic microscopic dissection as far as their terminal ramifications. From the lumbar plexus,...
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