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The extent and mechanisms by which neural input regulates skeletal muscle mass remain largely unknown. Adult spinal cord isolated (SI) rats were implanted unilaterally with a microstimulator, whereas the contralateral limb served as SI control (SI‐C). A 100‐HZ, 1‐s stimulus was delivered every 30 s for 5 min, followed by a 5‐min rest. This was repeated six times consecutively (SI‐Stim1) or with a...
The hypothesis we tested was that administering corticotropin‐releasing factor receptor agonists preserves muscle mass during cancer that is related to changes in tissue gene expression. cDNA microarrays were used to compare mRNAs from muscle and adipose tissues of non‐treated and agonist‐treated tumor‐bearing rats. In muscle of non–tumor‐bearing agonist‐treated animals we observed decreased expression...
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