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Introduction/Aims
We assessed the classification performance of machine learning (ML) using multifrequency electrical impedance myography (EIM) values to improve upon diagnostic outcomes as compared to those based on a single EIM value.
Methods
EIM data was obtained from unilateral excised gastrocnemius in eighty diseased mice (26 D2‐mdx, Duchenne muscular dystrophy model, 39 SOD1G93A ALS model,...
Introduction/Aims
Most mouse models of muscular dystrophy (MD) show mild phenotypes, which limits the translatability of experimental therapies to patients. A growing body of evidence suggests that MD is accompanied by metabolic abnormalities that could potentially exacerbate the primary muscle wasting process. Since thermoneutral (TN) housing of mice (~30°C) has been shown to affect many metabolic...
Sensory afferent fibers are an important component of motor nerves and compose the majority of axons in many nerves traditionally thought of as “pure” motor nerves. These sensory afferent fibers innervate special sensory end organs in muscle, including muscle spindles that respond to changes in muscle length and Golgi tendons that detect muscle tension. Both play a major role in proprioception, sensorimotor...
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