The current study focuses on the RegCM4.5 model and specifically on a comparison of hydrostatic and non‐hydrostatic approaches as well as on different microphysical parameterisations and planetary boundary layer (PBL) schemes. The main goal of the paper is to simulate the historical regional precipitation characteristics of the Carpathian region as reliably as possible. For this purpose, seven different model experiments at a 10 km horizontal resolution were completed for a 10‐year period (1981–1990) using ERA‐Interim reanalysis data (with 0.75° resolution) as initial and boundary conditions. Our simulation matrix consists of hydrostatic and non‐hydrostatic runs together with different treatments of moisture, namely, the SUBEX and the NogTom schemes. In addition, two PBL schemes are tested, the Holtslag and the UW‐PBL scheme. In this detailed validation study, RegCM outputs (e.g., temperature, global radiation, cloud cover, precipitation) are compared to the homogenized, gridded CarpatClim data (available with 0.1° resolution) that are based on measurements at regular meteorological station sites. The validation considers seasonal and monthly means, as well as extreme climatic events. On the basis of the results we can conclude that the role of the non‐hydrostatic core can be clearly recognized for precipitation, particularly over mountains. Moreover, it was also found that the UW‐PBL scheme performs with a negative bias regarding atmospheric boundary layer thickness and temperature and it reduces the wet/dry biases of the Holtslag PBL scheme. Regarding microphysical schemes, the NogTom scheme performs better than the SUBEX scheme, but the modified SUBEX (SUB4.3) can also reduce the precipitation over mountainous areas.