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Integrin α4β7 mediates both rolling and firm adhesion of lymphocytes by modulating its affinity to the ligand: mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1). Integrin activation is associated with allosteric reshaping in the β subunit I (βI) domain. A prominently conformational change comprises displacement of the α1 and α7 helices in the βI domain, suggesting that the location of these helices...
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