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The peptide T20, which corresponds to a sequence in the C‐terminal segment of the HIV‐1 transmembrane glycoprotein gp41, is a strong entry inhibitor of HIV‐1. It has been assumed that T20 inhibits HIV‐1 infection by binding to the trimer formed by the N‐terminal helical region (HR1) of gp41, preventing the formation of a six helix bundle by the N‐ and C‐terminal helical regions of gp41. In addition...
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