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Belonging to the dynamin superfamily of large GTPases, human guanylate‐binding proteins (hGBPs) comprise a family of seven isoforms (hGBP‐1 to hGBP‐7) that are strongly upregulated in response to interferon‐γ and other cytokines. Accordingly, several hGBPs are found to exhibit various cellular functions encompassing inhibitory effects on cell proliferation, tumor suppression as well as antiviral and...
Human guanylate‐binding protein 1 (hGBP‐1) shows a dimer‐induced acceleration of the GTPase activity yielding GDP as well as GMP. While the head‐to‐head dimerization of the large GTPase (LG) domain is well understood, the role of the rest of the protein, particularly of the GTPase effector domain (GED), in dimerization and GTP hydrolysis is still obscure. In this study, with truncations and point...
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