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Background Information
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell and whole‐body energy homoeostasis. REV‐ERBα is a nuclear receptor that plays an important role in metabolism. While mTORC1 activation is necessary for muscle differentiation, the role of REV‐ERBα is less clear.
Results
We studied the effect of REV‐ERBα overexpression and silencing as well...
Background information
Poly(ADP‐ribose) Polymerase‐1 (PARP‐1) is predominantly a nuclear protein and involved in various cellular processes like DNA repair, cell death, development, chromatin modulation etc. PARP‐1 utilizes NAD+ and adds negatively charged PAR moieties on the target proteins. Over‐activation of PARP‐1 has been shown to cause energy crisis mediated cell death in which mitochondrial...
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