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Conclusion The fast development and application of microscopic and new immunohistochemical tools, molecular and cytogenetic analytical methods results in a better identification of specific or clusters of subtypes in STS, and provides specific molecular targets to which selected agents are being developed. This allows for a further evaluation of the characteristics and chemo-sensitivity of these different...
Conclusion RT targeting of STS presents considerable challenges in realizing optimum outcome in tissue and function preservation while maintaining high local control for most anatomic sites. While a highly effective adjuvant, RT delivered improperly may cause substantial disability by excessive volume or dose delivery. The advent of very precise treatment planning and delivery systems, including 3D...
Conclusions Soft tissue sarcomas continue to represent a therapeutic challenge because of their rarity and the heterogeneity of the many histologic subtypes. The efficacy of preoperative therapy has been difficult to establish. However, there is evidence that induction therapy may result in reduction of tumor size that facilitates less radical surgical resections with improved postoperative function...
Conclusion The development of Imatinib has clearly created a new paradigm for the treatment of soft tissue sarcomas. Although long term follow-up data are yet lacking it is already quite evident the drug is nothing less than a break-through in the treatment of GIST. It will be of crucial importance in the next coming years to establish a functional relationship between presence of a target for treatment...
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