Effects of rice bran and soybean fermented with five different types of Bacillus spp. on lipid levels in the serum, liver, and feces of Sprague-Dawley male rats fed a high fat diet were investigated. Twenty-one rats were divided into three groups (n=7/group) and fed control diet (Normal), high fat diet (Control), and high fat diet supplemented with 0.4% of solid fermented material (SFM) (CF). Total lipid, triglyceride, and total cholesterol, as markers for the fatty liver, in the liver were significantly (p<0.0001) increased by high fat diet. Triglyceride and total cholesterol in serum were also significantly (p<0.0001 and p<0.01, respectively) increased by high fat diet. However, hepatic total lipid and triglyceride in the CF group were significantly decreased by 48.6% (p<0.0001) and 46.6% (p<0.0001), respectively, compared to the Control group. Serum triglyceride and total cholesterol in the CF group decreased by 40 (p<0.0001) and 5% (p<0.01), respectively, compared to the control group. These results suggest SFM could induce decrease of total lipids and triglyceride in the serum and liver. SFM may play an important role in the prevention of hyperlipidemia and could be used as a supplement for functional food preparation.