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Shape memory polymer (SMP) containing medical implants that are delivered through catheters require controlled expansion times to prevent the device from binding in the delivery catheter. Delayed expansion can be accomplished using body temperature and moisture plasticization from the aqueous environment of the blood. Although bulk material approaches are effective at delaying the expansion rate,...
Left-right (LR) asymmetry in cell orientation is known as a result of intracellular events such as cytoskeletal organization. However, the dependence of LR asymmetry on mechanical properties of surrounding microenvironment has been unknown. Here we show that the cellular LR behavior was altered when cultured on extracellular matrix with varied substrate rigidity. Using micro-patterned substrate with...
This work presents a super-resolution cell imaging method that uses an array of polystyrene (PS) micro-beads lenses embedded in an elastomer thin film on top of a glass substrate. The micro-beads lens array collects reflected near-field light waves from an object's surface and amplifies the waves to allow the formation of enlarged virtual images of the object. We have shown that object images could...
A novel pressure transmitter for assisting local pressure sensing in a microfluidic device is proposed aiming to improve on-chip single cell evaluation. By integrating the pressure transmitter into an existing pressure sensing technique, the local pressure in a microchannel can be directly determined. The pressure transmitter transmits the pressure from one microfluidic circuit to another without...
In this paper, we propose a new method to fabricate microchannels inside cell embedded hydrogel blocks using local heating from electrodes on a substrate for tissue engineering applications. The cell embedded hydrogel blocks are locally melted and the melted area can be used as microchannels as like vascular networks. The size and fabrication timing of the microchannels can be controlled by the proposed...
A microfluidic technology-based tissue-dissociation device has for the first time been designed, fabricated and characterized for the purpose of primary neuronal cell culture. The system has been utilized for controlled dissociation, under an oscillatory flow field, of freshly explanted, enzyme-treated Drosophila larval central nervous system (CNS) into individual, viable neurons capable of robust...
Carbon based nanostructures such as graphene and carbon nanotubes have received widespread attention due to their unique mechanical and electronic properties. This paper describes a quantum mechanics based study of the electronic band structures and transport properties of one-dimensional (1D) carbon chains, the thinnest nanowires available in nature. The study is based on the application of density...
Oligonucleotide-functionalizing noble metal nanoparticles (NMNPs) have resulted in many interesting applications in engineering, as well as in medicine. Typically, NMNPs are functionalized via thiol-metal interaction using thiol-labeled oligonucleotides. Previous studies have revealed that strong interactions exist between oligonucleotide bases and noble metal surface and these interactions are sequence-dependent...
Recognizing the microenvironmental cues that affect cellular morphology and mechanical properties will contribute to our general understanding of tumor cells, as well as provide approaches to develop effective anti-cancer therapies. Constructing the designated physical microenvironment in which the tumor cells exist is important for cancer cell studies. Although numerous studies have examined how...
We report a sensitive colorimetric detection of botulinum neurotoxin (BoNT) activity using gold nanoparticles (AuNPs). First, the SNAPtide modified with biotin and cysteine in its two ends, would be cleaved into two short peptides by BoNT activity. The unreacted and cleaved peptides with biotin would be removed by magnetic separation, leaving only cleaved peptides with cysteine end. Next, AuNPs were...
The increasing availability of genetic information demands more simple and rapid methodology for nucleic acid testing. To this end, cumbersome procedural steps with long amplification time (>1 hour) for polymerase chain reaction (PCR) have been a major challenge for rapid identification of genetic information. This paper addresses the challenge of rapidly identifying genetic information. Unlike...
A self-assembled novel nanocomposite composed of MoS2-Graphene nanosheets (MoS2-GNS) composites were electrostatically formed on top of gold (Au) electrode and their biochemical amplification responses were reported. The properties of the MoS2-GNS were characterized by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), and Fourier...
The wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on...
In cell injection, biological microscope is essential. It is commonly that intelligent microscope has many striking features, one of which is having a three-dimensional micro objective platform. The platform has the function of high precision positioning and automatic focus. In this paper, a novel single degree of freedom objective platform based on inertial stick-slip has been designed and fabricated,...
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